虾青素对四氯化碳致小鼠急性肝损伤与保护作用.docVIP

. . 　　 本文档下载自 HYPERLINK / 文库下载网，内容可能不完整，您可以点击以下网址继续阅读或下载：  HYPERLINK /doc/e175022c580216fc710afd0e.html /doc/e175022c580216fc710afd0e.html 虾青素对四氯化碳致小鼠急性肝损伤的保护作用 现代食品科技 Modern Food Science and Technology 2010, Vol.26, No.11 虾青素对四氯化碳致小鼠急性肝损伤的保护作用 刘安军，马天娇，陈影，王云霞，陶东川，张会 （天津科技大学食品工程与生物技术学院，天津 300457） 摘要：48只小鼠随机分为六组：空白组、模型组、联苯双酯阳性对照组及虾青素高、中、低剂量组，用腹腔注射CCl4造模成急性肝损伤，24 h后测定血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白（ALB）、总蛋白（TP）的含量，以及肝组织中过氧化物歧化酶(SOD)、丙二醛(MDA)的含量,探讨虾青素对四氯化碳（CCl4）致小鼠肝损伤的保护作用。结果表明：虾青素能显著降低CCl4致急性肝损伤小鼠血清ALT、AST活性，降低肝匀浆中MDA含量，提高SOD活性。 关键词：虾青素；四氯化碳；小鼠；急性肝损伤；保肝作用 文章篇号：1673-9078(2010)11-1197-1199 Protective Effect of Astaxanthin on the Acute Liver Injury Induced by CCl4 in Mice LIU An-jun, MA Tian-jiao, CHEN Ying, WANG Yun-xia, TAO Dong-chuan, ZHANG Hui (College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China) Abstract: To investigate the protective effects of astaxanthin on CCl4-induced acute hepatic injury in mice, forty-eight mice were divided into six groups (normal control group, CCl/doc/e175022c580216fc710afd0e.html4 model group, bifendate group, low dose, medium dose and high dose of astaxanthin group). Mouse models of acute liver injury were induced by intraperitoneal injection of CCl4. After 24 hours, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB) and total protein (TP) in serum and the content of malondialdehyde (MDA) and the activity of super oxide dismutase (SOD) in liver were detected. Results showed that the serum levels of ALT and AST in CCl4-induced liver injury mice were significantly decreased by astaxanthin treatment. And the activity of SOD was increased and the content of MDA was decreased in mice liver by astaxanthin. It was concluded that Astaxanthin has protective effects on the liver injury induced by CCl 4 in mice. Key words: astaxanthin; CCl4; mice; acute liver injury; hepatoprotection 虾青素(Astaxanthin)是发现于某些水生动物体内的一种类胡萝卜素，又名虾黄素，化学名称为3,3