ROC曲线评价MMP-2和MMP-9在类风湿关节炎诊断中的价值.docVIP

ROC曲线评价MMP-2和MMP-9在类风湿关节炎诊断中的价值 刘琴 魏建波 浙江省立同德医院检验科 浙江 杭州310012 摘要：目的 探讨关类风湿节炎（RA）患者血清MMP-2和MMP-9浓度变化及其临床价值。方法 RA 患者73例，将病例分成活动期RA组（43)和缓解期RA组（30)两组，骨关节炎（OA）组34例，健康对照组46例，用ELISA测定各组MMP-2和MMP-9水平，描绘受试者工作曲线（ROC）并进行曲线下面积（AUC）曲线分析。结果RA组血清MMP-2水平和血清MMP-9水平均显著高于对照组（P0.01）及OA组（P0.05）；组MMP-2和MMP-9均显著高于缓解期RA组（P0.05）。MMP-2诊断活动期RA的AUC为0.808，MMP-9诊断活动期RA的AUC为0.843，临界值分别为.9 ng/ml和.3 ng/ml；MMP-2诊断RA的AUC为0.733，MMP-9诊断RA的AUC为0.760，临界值分别为.9 ng/ml和.8 ng/ml，两项联合诊断RA的AUC为0.878。结论 MMP-2和MMP-9对RA的诊断均具有较好的诊断和鉴别诊断价值，两者联合更利于RA的诊断和病情评估。 关键词：ROC MMP-2; MMP-9 ; 类风湿关节炎 基金项目：浙江省科技厅基金资助项目(编号：2012C37044) 作者简介：刘琴，女，硕士研究生E-mail：liuqi ROC curve MMP-2 and MMP-9 in patients with rheumatoid arthritis diagnosisLIU Qin WEI Jianbo Tongde Hospital of Zhejiang Province, Hangzhou, 310012, China Abstract: Objective Explore related rheumatoid arthritis (RA) patients with serum MMP-2 and MMP-9 concentration and clinical value. Methods RA patients, 73 cases, the patients were divided into active RA group (n = 43) and remission RA group (n = 30) groups, osteoarthritis (OA) group of 34 cases, 46 cases of healthy control group. Each group was measured by ELISA MMP-2 and MMP-9 levels, depicting the receiver operating curve (ROC) and area under the curve (AUC) curve analysis. Results RA serum levels of MMP-2 and MMP-9 serum levels were significantly higher (P 0.01) and the OA group (P 0.05). Active RA group, MMP-2 and MMP-9 were significantly higher remission RA group (P 0.05). MMP-2 diagnosis of active RA, the AUC was 0.808, MMP-9 diagnosis of active RA, the AUC was 0.843, the critical values were 479.9ng/ml and 698.3ng/ml. MMP-2 diagnosis of RA AUC was 0.733, MMP-9 diagnosis of RA AUC of 0.760, the critical values were 153.9ng/ml and 197.8ng/ml, two combined diagnosis of RA AUC = 0.878. Conclusion MMP-2 and MMP-9 diagnosis for RA have better diagnosis and differential diagnosis, their combination is more conducive to the RA diagnosis and disease assessment. Key words: ROC; MMP-2; MMP-9; Rheumatoid a