帕利哌酮缓释片合并银杏叶提取物治疗精神分裂症的临床对照.docVIP

帕利哌酮缓释片合并银杏叶提取物治疗精神分裂症的临床对照观察 方永修 （上海市崇明县精神卫生中心，上海 崇明 202150） 电话 【摘要】 目的 比较帕利哌酮缓释片合并银杏叶提取物与帕利哌酮缓释片治疗精神分裂症的疗效和不良反应。 方法 将符合ICD -10诊断标准的精神分裂患者分为两组，一组给予帕利哌酮缓释片合并银杏叶提取物治疗（治疗组，n=40）,另一组给予帕利哌酮缓释剂治疗（对照组，n=37），疗程6周。用简明精神病评定量表（BPRS）在治疗前及治疗1、2、4、6周末评定疗效，用副反应量表（TESS）评定不良反应。结果BPRS 两组总体疗效有显著差异：帕利哌酮缓释片合并银杏叶提取物治疗组对精神分裂症起效较快，不良反应没有明显增加。但2周后 BPRS减分率的改变则无明显差异。结论帕利哌酮缓释片合并银杏叶提取物治疗精神分裂症比单用帕利哌酮缓释片起效更快，但2周后BPRS减分率的差异无统计学意义，可以不必继续联合使用银杏叶提取物。 【关键词】银杏叶提取物；精神分裂症；帕利哌酮缓释片；BPRS A clinical study of paliperidone extend-release tables and combined utilization of ginkgo biloga extract in the treatment of schizophrenia .FANG Yong Xiu. Chongming Mental Health Center ,202150, Shanghai China 【Abstract】 Objective To compare clinical efficacy and the side effects between combined utilization of ginkgo biloba extract and paliperidone extended - release tables and only the use of paliperidone extended - release tables in the treatment of schizophrenia. Methods seventy-five patients with schizophrenia were treated randomly with combined utilization of ginkgo biloga extract and paliperidone extend-release tables only for six weeks ,and measured with the brief psy- chiatric rating scale (BPRS) and treatment emergent symptom scale (TESS) before treatment and 1,2,4,6 weeks after treatment. Results The both programes were different in efficacy, combined utilization of ginkgo biloga extract and paliperidone extended - release tables is more effective than paliperidone extended - release tables only in treating schizophrenia,and the side effects combined utilization of ginkgo biloga extract and paliperidone extend-release tables is no more effective than paliperidone extend-release tables only in treating schizophrenia. Conclusion The therapentic effect of combined utilization of ginkgo biloga extract and paliperidone extend-release tables take a active part earlier than only the use of paliperidone extend-release tables in the treatment of schizophreni