局部温热联合WR-1治疗皮肤疣%3a随机对照试验.pdfVIP

目 录 一、摘要 中文论著摘要····················································2 英文论著摘要····················································3 二、英文缩略语······················································4 三、论文 前言···········································-················5一刖舌。’。。·’。。。。。‘‘。。‘·。‘。。‘。。‘。’‘。。。。’’’。。。’‘。。。。。。。。。。‘。。‘‘。。‘’。 临床资料························································5 结果····························································8 讨论与结论·····································一一一”一．．一一·9 四、本研究创新性的自我评价··········································11 五、参考文献·······················································12 六、附录 综j签···························································14 在学期间科研成绩···············································27 致谢···························································28 个人简介·······················································29 ·中文论文摘要· 局部温热联合WR-1治疗皮肤疣：随机对照试验 目的 局部温热疗法是一种治疗病毒疣的新方法。我们尝试局部温热治疗联合一种 新型的免疫刺激剂(WR-1)治疗皮肤病毒疣。为了探索温热联合新型免疫刺激剂 (WR-1)治疗病毒疣的效果，我们设计了一个临床随机对照实验。 方法 采用随机对照、单盲的临床试验研究方法。112名门诊病毒疣(包括跖疣、寻 常疣)患者被随机分配成两组：温热一药物组(wR一1)和温热一安慰剂(生理盐水) 组。对患者的一个疣体(选择最大或疼痛最明显的疣体)外涂WR-1或安慰剂，5分钟 20072 后，用温热治疗仪(专利号：ZL 0185403．3：中国医科大学)对疣体进行 加热，设定皮肤表面温度为42C(寻常疣)或44。C(跖疣)，持续30分钟。连续 治疗3天，间隔15天后，再连续治疗2天。治疗结束后随访3个月。主要观察指标是 3个月时的治愈率(多发疣患者，疣体全部脱落)。 结果 治疗后3个月，温热-药物组(wR-1)66％(39／59)的患者痊愈，温热．安慰剂组 38％(19／50)的患者痊愈(p．05)。疣体脱落后无瘢痕及色素沉着。两组疗效均与患 者年龄、疣体数量和疣体大小无关。药物组疗效与病程有关，病程大于6个月的 患者治愈率较低(p．05)。痊愈患者继续随访至六个月，未见复发。 结论 1．联合此新型免疫刺激N(WR．1)可以明显提高温热疗法对皮肤病毒疣的治愈 率。 2．疗效与患者年龄、疣体数量和疣体大小无关。 关键词 温热，疣，治疗 2 ·英文文论文摘要· Local combinedwithwr-1or hyperthermia