Glioma Diffusion kurtosis MR Imaging in grading翻译.docVIP

Glioma : Diffusion kurtosis MR Imaging in grading Purpose：To assess the diagnostic accuracy of diffusion kurtosis magnetic resonance imaging parameters in grading gliomas 目的：评价磁共振参数扩散峰度成像在诊断脑胶质瘤分级中的准确性。 Materials and methods: The institutional review board approved this prospective study, and informed consent was obtained from all patients.材料与方法：学术机构审查委员会批准了这项前瞻性研究，并获得知情同意的患者。 Diffusion parameters—mean diffusivity (MD),fractional anisotropy (FA), mean kurtosis, and radial and axial kurtosis—were compared in the solid parts of 17 high-grade gliomas and 11 low-grade gliomas (P＜0.5 significance level, Mann-Whitney-Wilcoxon test, Bonferroni correction).扩散参数包括平均扩散率（MD），各向异性分数（FA），平均峰度，径向峰度和轴向峰度。这些参数在17例高级实体胶质瘤和11例低级实体胶质瘤中作比较，通过Mann-Whitney秩和检验，Bonferroni校正来进行数据分析，当P＜0.5，差异有统计学意义。 MD, FA, mean kurtosis, radial kurtosis, and axial kurtosis in solid tumors were also normalized to the corresponding values in contralateral normal-appearing white matter (NAWM) and the contralateral posterior limb of the internal capsule (PLIC) after age correction and were compared among tumor grades.经过年龄校正后，参照对侧正常白质（NAWM）和对侧内囊后肢（PLIC）的相应值，将实体肿瘤的MD、FA、平均峰度、径向峰度与轴向峰度标准化，并与肿瘤等级对照。 Results: Mean, radial, and axial kurtosis were significantly higher in high-grade gliomas than in low-grade gliomas (P = .02, P = .015, and P = .01, respectively) FA and MD did not significantly differ between glioma grades. . All values, except for axial kurtosis, that were normalized to the values in the contralateral NAWM were significantly different between high-grade and low-grade gliomas (mean kurtosis,P = .02; radial kurtosis, P = .03; FA, P = .025; and MD, P = .03). 结果：高级胶质瘤平均、径向峰度和轴向峰度都高于低级胶质瘤（分别为P=0.02、P=0.015 和 P=0.01）。 不同等级的胶质瘤FA和MD差异无统计学意义。除轴向峰度外，高级与低级胶质瘤的所有参数值参照对侧 NAWM参数值标准化后均有差异。（平均峰度，P =0.02；径向峰度，P =0.03；各项特异性P =0.025；平均扩散率P =0.03）。 When values were normalized to those in the contralateral PLIC, none of the considered parameters showed significant differences between high-grade and