氟比洛芬酯对切口痛大鼠痛行为及脊髓c-fos蛋白表达的影响.pdf

山西医科大学硕士学位论文 1.2 英文摘要 1.2 英文摘要 11..22 英英文文摘摘要要 Theeffectofflurbiprofenaxetilinjectionon painbehaviorandspinalc-fos Theeffectofflurbiprofenaxetilinjectionon painbehaviorandspinalc-fos TThheeeeffffeeccttoofffflluurrbbiipprrooffeennaaxxeettiilliinnjjeeccttiioonnoonnppaaiinnbbeehhaavviioorraannddssppiinnaallcc--ffooss expressionin aratmodelofincisionalpain expressionin aratmodelofincisionalpain eexxpprreessssiioonniinn aarraattmmooddeellooffiinncciissiioonnaallppaaiinn Objectve: Objectve: OObbjjeeccttvvee:: Compare the analgesic effect of flurbiprofen axetil on incisional pain in rats by giving different doses of flurbiprofen axetil at two time points,discuss the preventive analgesic effect of flurbiprofen axetil . (1)To observe the effect of preemptive analgesia by injection different doses of flurbiprofen from the tail vein onthe rat model of incisional pain; (2)Compare theanalgesic effect ofthe two different point (before and after surgery); (3)Toprovide the basis for preemptive analgesia for theclinical use offlurbiprofen axetil. Methods: Methods: MMeetthhooddss:: 64 male SD rats were randomly assigned to 8 groups (n = 8). The experiment was divided into two main parts (F and C). F part and C part each contained four groups, saline group (F1, C1 group), flurbiprofen axetil 1,5,9 mg / kg groups respectively(F2, F3, F4 group, C2, C3, C4group ). F part: 20min before the operation were given saline or different doses of flurbiprofen axetil . C part: 20min after the operation were given saline or different doses of flurbiprofen axetil .Use cumulative pain score test toevaluate the pain behavior, and 2 hours later,kill the 9rats,remove the spinal cord and examine the fos expression by using immunohistochemistry method . Results: Results: RReessuullttss:: (1)F part: C