婴幼儿血管瘤发生发展与消退：干细胞、内皮细胞及细胞因子的参与及作用.docVIP

婴幼儿血管瘤发生发展与消退：干细胞、内皮细胞及细胞因子的参与及作用 苗晓腾，宋维铭 中国医学科学院?北京协和医学院?整形外科医院面颈部整形美容中心，北京市? 100144 Role of stem cells, endothelial cells and cytokines in the development and regression of infantile hemangioma Miao Xiao-teng, Song Wei-ming Department of Cervicofacial Plastic and Reconstructive Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100144, China 摘要? 背景：目前尚缺少对血管瘤的有效治疗，其原因在于对其发病机制的认识仍不清楚。目的：回顾分析近年来有关血管瘤流行病学特点、病理生理特点及发病机制的文献，认识目前有关血管瘤发病机制的研究进展，为血管瘤发病机制的研究及药物治疗的研发提供线索。方法：计算机检索PubMed数据库2009年1月至2014年2月有关血管瘤发病机制、病理生理特点及流行病学数据的研究，检索主题词分别为“hemangioma，capillary，classification，epidemiology，etiology，embryology; cytology，physiopathology，pathology，immunology，genetics，drug therapy，therapy”。结果与结论：血管瘤发生、发展及消退的研究已取得显著进展，但目前对血管瘤还缺少大样本、多中心的流行病学统计数据，对血管瘤发病机制尚未提出完善的学说，各学说研究对象多为某一单一因素，各因素之间的相互关系尚未明确。血管瘤发病机制研究的瓶颈在于缺少完善的动物研究模型，而现有血管瘤裸鼠研究模型存在一定限制，积极研发新的动物研究模型是血管瘤发病机制研究的关键。 中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程 全文链接： 关键词?：?组织构建；?血管内皮细胞；?婴幼儿血管瘤；?血管瘤内皮祖细胞；?血管瘤内皮细胞；?脐静脉内皮祖细胞；?内皮祖细胞；?干细胞；?增殖；?消退；?血管发生；?血管生成； ?? Abstract： BACKGROUND:?At present, there are few efficient therapies for infantile hemangioma, and the pathogenesis mechanisms remain unclear.?OBJECTIVE:?To review the literatures available on the epidemiology, pathophysiology and pathogenesis of infantile hemangioma, to understand the research progress on the pathogenesis of infantile hemangioma, and to provide a reference for developing new drug therapies.METHODS:?A computer-based online search was performed in the PubMed database for literatures related to the pathogenesis, physiopathological features and epidemiology data of infantile hemangioma published from January 2009 to February 2014. The subject headings are “hemangioma, capillary, classification, epidemiology, etiology, embryology, cytology, physiopathology, pathology, immunology, genetics, drug therapy, therapy”.?RESULTS AND CONCLUSION:?Accumulating evidence has investigated the occu