西沙必利片促胃动力作用的药效学研究.docVIP

西沙必利片促胃动力作用的药效学研究 刘元1，杨斌2，李星宇1，宋志钊 1 （1广西中医药研究院，南宁 530022 2 广西医科大学药理学教研室 南宁 530021） 摘要：[目的]观察国产西沙必利片促胃动力作用，并以进口普瑞博思片作比较。[方法] 采用小鼠炭末排出时间、大鼠碱性反流性胃炎模型，大鼠胆汁分泌流量测定等实验方法观察西沙必利片的药效学作用。[结果] 西沙必利片能使小鼠胃肠推进速度加快，明显缩短炭末排出时间；亦能明显抑制大鼠幽门扩张和十二指肠液反流入胃后所造成的慢性胃炎反生率；并能明显增加大鼠胆汁分泌流量，且同等剂量的西沙必利片与进口普瑞博思片药理作用基本一致。[结论] 西沙必利片具有促胃动力作用。 关键词：西沙必利片；普瑞博思片；胃动力 Observing The Pharmacological Effect On Improving Gastric Motility By Cisapride Talbets LIU Yuan1 YANG Bin2 LI Xing-yu1 SONG Zhi-zhao1 1: Guangxi Institute for Chinese Medicine ＆ Pharmaceutical Science,Nanning 530022,China 2: Guangxi Medical University Pharmacology Department, Nanning 530021, China [Abstract]Objective: To observe the effect on improving gastric motility by domestic cisapride tablets and compare with imported prepulside. Methods: Through the model of mice by recording the time of excreting carbo medicinalis, the rats model of alkaline reflux gastritis, determine bile secrete flow in rats to observe the pharmacological role of cisapride talbets. Result: The cisapride talbets could significantly expedite gastrointestinal force, it could significantly shortened the time of excreting carbo medicinalis, it could significantly inhibit the pylorus dilatation in rats and inhibit occur rate of duodenal juice reflux gastric induced chronic gastritis, it also could significantly increase bile secrete flow in rats, and the same dosage cisapride tablets and imported prepulside have the basic pari passu pharmacological effect. Conclusions: The cisapride talbets had the pharmacological role of improving gastric motility. [Key word] cisapride talbets; prepulside talbets; gastric motility 西沙必利(Cisapride)，又名普瑞博思，是苯甲酰胺衍生物。西沙必利作为一种新型的促动力药，能加强胃肠道收缩和刺激胃排空，改善功能性消化不良等症状，临床上用于功能性消化不良、糖尿病胃轻瘫、术后胃轻瘫、特发性胃轻瘫、神经性厌食等胃动力障碍。本文根据与治疗作用有关的主要药效学试验来观察西沙必利片的促胃动力作用，现将结果报告如下。 1 材料 1.1 动物 昆明小鼠，普通级，合格证号:桂医动字第11004号，Wistar大鼠，普通级，合格证号:桂医动字第11005号，均由广西中医学院动物实验中心提供。 1.2 药物 西沙必利片,5mg/片，由广西田丰制药有限公司提供。普瑞博思片，5mg/片，批号：0107104，西安杨森制药有限公司产品。 2 方法与结果 2.1 西沙必利片对小鼠炭末排出时间的影响[