黄小龙辛伐他汀在治疗例冠心病中调脂效果分析MicrosoftWord文档.docVIP

辛伐他汀在治疗120例冠心病中调脂效果分析 黄小龙 [摘要] 目的：分析辛伐他汀在冠心病调脂治疗过程中的作用和效果。方法：运用辛伐他汀10mg、20mg分别对冠心病合并或不合并高血脂症的患者进行治疗，并在治疗后1月、3月、6月检查患者的TC、TG、LDL-C、HDL-C、AST、BUN、Cr的变化情况，来观察治疗效果和药物的依从性。结果：对于伴有高血脂症的患者两组TC、HDL-C治疗效果相似，但20mg 组TG、LDL-C效果明显好于10mg组；对于不伴有高血脂症的患者两组的TC、TG、LDL-C都降低，无明显差异性，HDL-C两组都升高，有明显差异性；患者的AST、BUN、Cr都没有变化。结论：对不合并高血脂症的冠心病患者选择辛伐他汀10mg；对合并高血脂症患者选择20mg，当血脂恢复正常后，改为10mg维持，是一个既能够保证治疗效果，又能提高药物的依从性的治疗方案，值得在基层医院推广。 [关键词] 辛伐他汀；冠心病；调脂作用；药物疗效观察 The effect of simvastatin in the treatment of 120 cases of coronary heart disease analysis Huang Xiao-long [Abstract] Objective: analysis of simvastatin in patients with coronary heart disease and the effect of regulating role in the process of lipid therapy. Methods: Patients with simvastatin 10mg, 20mg were not associated with hyperlipidemia in coronary or treatment, changes in January, and in March June after treatment, patients were examined TC, TG, LDL-C, HDL-C, AST, BUN, Cr, to observe the therapeutic effect and drug compliance. Results: the effect of the two groups of TC, HDL-C in treatment of patients with hyperlipidemia is similar, but the 20mg group of TG, LDL-C was better than group 10mg; for patients without hyperlipidemia in two groups of TC, TG, LDL-C decreased, but no significant difference in two groups, HDL-C increased, with significant difference of the patients, BUN, AST; Cr had no change. Conclusion: the choice of simvastatin 10mg without combined hyperlipidemia in patients with coronary heart disease complicated with hyperlipemia; for patients with 20mg, when the blood return to normal after, to 10mg to maintain, is a not only can ensure the treatment effect, but also can improve the compliance of treatment drugs, worthy of promotion in the primary hospital. [keyword] simvastatin; coronary heart disease; lipid metabolism; curative effect observation 冠心病是冠状动脉硬化性心脏病的简称，由于冠状动脉粥样硬化，使心脏的各级动脉血管的管腔发生狭窄或阻塞，在一定的诱因作用下，导致心肌的缺血而引发一系列的临床症状，其病理基础是冠状动脉的粥样硬化。根据中华医学会心血管分会2007年冠心病诊断和治疗指南和2008年指南更新，调脂是治疗冠心病的重要措施之一【1】。随着临