抗肿瘤创新药物的研究进展.pdfVIP

C h in ese Jou rna l o f N ew D rug s 20 10, 19 (24 ) , (第二军医大学药学院, 上海 200433) [] 肿瘤是影响人类健康的重大疾病之 一, 近年来随着多 因素的影响, 肿瘤的发病率呈不断上 升趋势经过 60多年的发展, 抗肿瘤药物在提高患者生存时间和改善生活质量方面取得了明显进展, 近 10 年 FDA 先后批准 40 个抗肿瘤新分子实体药物上市分子靶向药物的临床使用经验表明开发不易耐药的多 靶点激酶抑制剂和高效低毒的细胞毒类药物仍是抗肿瘤创新药物研发的主体 [] 抗肿瘤; 创新药; 分子靶向药物; 细胞毒药物; 激酶抑制剂; 天然产物 [] R979. 1 [] A [] 1003- 3734(2010) 24- 2277- 09 Developm ent of novel anticancer drugs ZHANG Wannian, M IAO Zhenyuan (School of Pharmacy, SecondM ilitaryM edical University, Shanghai 200433, China) [Abstract] Tumor is one of the diseases greatly influencing humans health. W ith the changes of various factors in recentyears, the tumormorbidity shows a tendency to rise constantly. The antineoplastic drugs in mi pro ving survival and life quality of patients have achieved significant progress since 1940s. In recentyears, forty new antineoplastic drugs have been proved by FDA. The use of tyrosine kinase inhibitors in clinicalpractice has indica ted thatmultitargeted kinase inhibitors and cytotoxic drugsw ith lower toxicity w ill be themain body of antineoplastic drug research in future. [K ey words] anticancer; novel drug; molecular targeted drug; cytotoxic drug; kinase inhibitors; natural product , 10 FDA , , 12, 16, 8 20 40 , 4 , 60, 100 , , [ 1] 1 2001- 2010 FDA 2001- 2010 FDA 40 , 2004 8 , 22. 2% ( 1) 1 2001- 2010FDA() () [] 张万年, 男,教授, 博士生导师,主要从事抗肿瘤和抗真菌