我院大肠埃希菌耐药率与抗菌药使用量的相关性研究.pdfVIP

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 药物与临床　 我院大肠埃希菌耐药率与抗菌药使用量的相关性研究 危华玲　 农生洲　 (广西壮族自治区人民医院　 南宁530021) 摘　 要　 目的:探讨大肠埃希菌耐药率与抗菌药使用量之间的关系,为临床合理使用抗菌药提供参考。 方法:采用回顾性调 查方法,统计2010~2012年我院12种抗菌药使用强度(AUD)及同期大肠埃希菌耐药率,并对抗菌药使用量与耐药率进行多 元线性回归分析。 结果: 大肠埃希菌对头孢他啶、头孢噻肟、氨曲南的耐药率与哌拉西林/ 他唑巴坦用量呈负相关(r = -0.700、-0.717、-0.647,P0.05);对头孢他啶、头孢噻肟耐药率与头孢他啶用量呈正相关(r=0.662、0.601,P 0.05);对 亚胺培南的耐药率与亚胺培南用量呈正相关(r=0.685,P0.05)。 结论:大肠埃希菌对抗菌药耐药水平变化与抗菌药使用 量之间存在相关关系,应加强抗菌药合理应用的管理,以控制和减缓细菌耐药性的增长。 关键词　 大肠埃希菌;抗菌药;耐药;相关性 + 中图分类号:R378.2 1　 　 文献标识码:A　 　 文章编号:1008-049X(2014)05-0822-03 Study on Relationship between Antimicrobial Consumption and Resistance of Escherichia Coli in Our Hos- pital Wei Hualing,Nong Shengzhou (People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning530021,China) ABSTRACT　 Objective:To investigate therelationshipbetweenantimicrobialconsumptionandresistanceofEscherichiacoli. Meth- ods:The total antibiotics use density(AUD) and the synchronous resistance rate of Escherichia coli were studied and the correlation between them was analyzedretrospectivelyusingmultiplelinearregressionanalysisinourhospitalfrom2010to2012. Results:There- sistance rateofEscherichiacoiltoceftazidime,cefotaximeandaztreonamwerenegativelycorrelatedwiththeconsumptionofpiperacillin/ tazobactam (r= -0.700,-0.717, -0.647,P 0.05). A significant positive correlation was found between the resistance rate to ceftazidime and cefotaxime and the consumption of ceftazidime(r =0.662,0.601,P 0.05). The resistance rate to imipenem had a significant positive correlationwiththe consumption of imipenem(r=0.685,P0.05) aswell. Conclusion:Arelationship existsbe- tween antimicrobial consumption and resistance rate of Escherichia coil. It is necessary to strengthen the management of microbacterial rational use to control and reduce the increase of bacterial resistance. KEY WORDS　 Escherichia coli;Antimicrobial;Resistance;Relationship 　 　 大肠埃希菌是人和动物肠道中的正常栖居菌,为条件致