肝细胞生长因子受体c—met在骨肉瘤中的表达及其临床意义.pdfVIP

现代肿瘤医学 2010年2月 卷筮 · 36l- 肝细胞生长因子受体 c—met在骨肉瘤中的表达及其临床意义 刘云燕，纪振钢，杨连甲，文艳华，裘秀春，张殿忠，马 琼，许 啸，范清宇 ExpressionofC——metandtheclinicalsignificanceandprognosticvalueinosteosarcoma LIUYun—yan，JIZhen—gang，YANGLian—jia，WENYan—hua，QIUXiu—chun，ZHANGDian—zhong，MA Qiong，xuXiao，FANQing—yu OrthopedicsOncologyInstituteofChinesePLA，TangduHospital，theFourthMilitaryMedwalUnwemity，Xian710038，China． A【bstract】 Objective：ToobservetheexpressionofC—metinosteosarcoma，andinvestigateitsclinicalsignifi- canceandprognosticvalue．M ethods：Theintegratedclinical datawereretrospectivelyanalyzedof35 osteosarcoma and13osteoidoseomapatientswhowereundergoneradicaloperation，andtheparaffin—embeddedtissuesofthechor- domasamplesweTecollected．TheexpressionofhepatocytergowthfactorreceptorC—metwasdetectedwithimmuno— histochemicaltechnique．TherelationshipsbetweenC—metandclinicalvariableswereanalyzed．Results：Th epositive expressionrateofC—metin35patientswithosteosarcomawas80％(28／35)，andsingificantlyhigherthanthatinthe patientswithosteoidosteoma(7．7％，P0．01)．In30patients，anegativecorrelationWasfoundbetweentheexpres— sionofC—metandsex，age，time，tumorsize，aswellaspahtologytypes，withoutstatisticalsingificance(P0．05)， buttherewasapositivecorrelationwithclinicalstagesandhtemetastasisofosteosarcoma(P0．05)．Conclusion： TheabnormalexpressionofC—metisanimportantadverseprong osticfactorforsurvival inosteosareom patients．C— metmaybemarkerofdiagnosisandprong osisinosteosracoma． K【eywords】hepatocytergowthfactorreceptorC—met；osteosarcoma；invasion；metastasis Modem Oncology2010，18(02)：0361—0363 摘【要】 目的：探讨骨肉瘤组织中肝细胞生长因子受体C—met蛋白的表达情况，分析其临床意义及与预后 的关系。方法：应用免疫组织化学方法检测行手术的35例骨肉瘤及 13例骨样骨瘤患者标本肝细胞生长因子 受体C—met的表达，并分析其与临床因素和预后的关系。结果：骨肉瘤组织中肝细胞生长因子受体 c—met 的阳性表达率为80％(28／35)，而在骨样骨瘤中的表达率为7