蚊虫抗药性分子机制研究进展_刘宏美.pdfVIP

·366 · 中国媒介生物学及控制杂志2012 年8 月第23 卷第4 期 Chin J Vector Biol Control, August 2012, Vol.23, No.4 ·综 述· 蚊虫抗药性分子机制研究进展 刘宏美，代玉华，公茂庆 山东省医学科学院，山东省寄生虫病防治研究所，山东济宁272033 摘要：蚊虫是重要的医学昆虫，可以通过叮咬传播疾病（例如疟疾、丝虫病、登革热等），其行为与人类生活息息相关。由 于长久以来大量、广泛地使用杀虫剂，使蚊虫抗性日益严重。蚊虫的抗性机制主要有靶标抗性（包括神经轴突钠离子通 道、乙酰胆碱酯酶和γ-氨基丁酸受体氯离子通道的突变）和代谢抗性（包括非特异性羧酸酯酶、细胞色素P450 和谷胱甘 肽-S-转移酶的活性增加）两方面。现对这些机制的研究进展进行综述，试图全面了解大量、广泛使用杀虫剂之后蚊虫抗 性产生的分子机制。 关键词：蚊虫；抗药性；靶标抗性；代谢抗性 + 中图分类号：R384.1；S481 .4 文献标志码：A 文章编号：1003-4692 （2012）04-0366-04 Advances in the molecular mechanisms of mosquito resistance to insecticides LIU Hong⁃mei, DAI Yu⁃hua, GONG Mao⁃qing ShandongAcademyofMedicalSciences, ShandongInstituteofParasiticDiseases, Jining272033, ShandongProvince, China Correspondingauthor: GONG Mao⁃qing, Email: maoqingg@ Supported by the International Science and Technological Cooperation Project of Shandong Province （No. LKH09-187-06），the Natural Science Foundation of Shandong Province （No. ZR2010HL020）and Excellent Young Scientist Research Award Projects of Shandong Province （No. bs2011SW032） Abstract: Mosquitoes, which act as important medical insects, can transmit diseases such as malaria, fiariasis and dengue fever, etc. by bites, being harmful to humans. For a long period of time, due to the extensive use of chemical insecticides, the insecticide resistance in mosquitoes is becoming more and more serious. The mechanisms of resistance can be classified into two groups, knockdown resistance (such as saltations in sodium channel, Acetylcholinesterase and γ-aminobutyric acid) and metabolic resistance (such as augmen