国产舒芬太尼在先天性心脏病与风湿性瓣膜病患者体内的药代动力学比较.pdfVIP

国产舒芬太尼在先天性心脏病与风湿性瓣膜病患者 体内的药代动力学比较 张竞超 (郑州大学第一附属医院心外科，河南郑州450052) 摘要：目的比较国产舒芬太尼在先天性心脏病及风湿性瓣膜炎患者体内的药代动力学特征：方法随机选取在医院进行手术治疗的先 天性心脏痛患者及风湿瓣膜病患者各16例，两组患者均应用国产舒芬太尼进行治疗，测定患者的血浆舒芬太尼浓度及药代动力学参 数。结果舒芬太尼的药代动力学符合开放三室模型，两组间的药代动力学参数有明显差异(P0．05)。结论国产舒芬太尼在先天性 心脏病及风湿性瓣膜病患者的药代动力学符合三室模型，患者的疾病类型及接受的手术类型会影响舒芬太尼的药代动力学特征。 关键词：舒芬太尼；先天性心脏病；风湿性瓣膜炎；药代动力学 中图分类号：11969．1；R971+．2文献标识码：A 文章编号：1006—4931(2014)09—0010—02 ofInVivo of SufentanilinPatientswith ComparativeAnalysis PharmacokineticsDomestic HeartDiseasesandImeumaticValvularDisease Congenital ZhangJingchao r Cardiac 450052J Departmentof Surgery，FirstAffiliatedHospitalofZhengzhouUniversity，Zhengzhou，Henan，China in ofdomesticsufentanilin the with heart To and the vivo patientscongenital Abstract：Objectiveexplorecompare pharmacokinetics Sixteen with heartdiseaseandSixteen withrheumaticvalvulitis diseaseandrheumaticvalvulitis．Methods patientscongenital patients coneen— treated in our were selected．Thetwo wereall thesufentaniltreatment．The byoperationhospitalrandomly groups given plasma The ofsufentanilaecordedwiththe trationofsurentanilandthe weredetected．ResultsDharmacokinetics pharmacokineticparameters three model．the had differencesbetweenthetwo open compartmentp