房颤中心房钾离子通道重构机制及相关药物的研究进展.pdfVIP

中华临床医师杂志( 电子版)2014 年1 月第8 卷第1 期 Chin J Clinicians(Electronic Edition),January 1,2014,Vol.8,No.1 ·145 · ·综述· 房颤中心房钾离子通道重构机制及相关药物的研究进展 苏昕 徐健 【摘要】 心房颤动（简称房颤）是临床上最常见的持续性快速心律失常之一，可以引起心房内 血栓、脑栓塞等严重并发症，是我国70 岁以上老年人发病率较高、致死率较高的一种疾病。房颤的 发生机制较为复杂，大量研究表明，心脏离子钾通道重构在房颤的发生和持续存在中发挥极其重要 的作用。作用靶点位于钾离子通道的药物已应用于心房颤动，虽有一定的疗效但仍存在效果欠佳， 并发症较多等缺点，现阶段关于心房钾离子通道重构及新型钾离子通道药物已经成为房颤研究中的 热点之一。 【关键词】 心房颤动； 心房电重构； 钾离子通道重构； 新型钾离子通道药物 Progress of potassium channel remodeling and related drugs in atrial fibrillation Su Xin, X u Jian. Department of Cardiology, Provincial Hospital Affiliated to Anhui Medical University, Hefei 236000, China Corresponding author: Xu Jian, Email: 958532006@ 【Abstract 】 Atrial fibrillation (AF) is one of the most common clinical sustained tachyarrhythmia, which can cause serious complications like atrial thrombosis, cerebral embolism. It is a high incidence, high mortality rate disease in more than 70 years old people. The mechanism of atrial fibrillation is complex, a large number of studies have shown that cardiac potassium ion channel remodeling plays an extremely important role in the occurrence and persistence of atrial fibrillation. The drugs which are located in potassium ion channel targets have been used in atrial fibrillation, which have although some effect but there are still ineffectiveness, more complications and other shortcomings. However, new potassium channel potassium ion channel drugs have become one of the hotspots in atrial fibrillation research. 【Key words 】 Atrial fibrillation; Atrial electrical remodeling; Potassium channel remodeling; Novel potassium ion channel drugs 房颤是临床实践中最常见的心律失常，中国 钾离子通道为靶点的药物的疗效。本文就房颤中心 70 岁以上老人发病率高达3.1%[1]