黄芩苷固体自乳化颗粒剂的制备.pdfVIP

窑制剂与技术 窑 中国医药导报 2014年7月第 11卷第 19期 黄芩苷固体自乳化颗粒剂的制备 高永艳1 陈海文1 梁超峰2银 1.广东省中医院药学部袁广东广州 510370曰2.广州医药研究总院有限公司袁广东广州 510240 [摘要] 目的研究黄芩苷固体自乳化颗粒剂的制备工艺遥 方法 通过溶解度考察尧伪三元相图的绘制及L 渊3 冤正9 3 交试验袁以形成自乳化效果尧自乳化时间和粒径的大小为指标袁选择最佳自乳化处方遥 通过对固体吸附材料的筛 选袁累积溶出度的测定袁筛选黄芩苷固体自乳化颗粒的最佳处方遥 结果最佳处方油酸乙酯-吐温渊Tween冤80-聚 乙二醇渊PEG冤400 的质量比为2颐7颐6袁可溶性淀粉与黄芩苷固体自乳化释药系统渊S-SEDDS冤的质量比为4颐1袁45 min溶出度达 102.89%遥 结论黄芩苷S-SEDDS制备方法简单袁稳定性好袁可以提高药物的溶出度遥 [关键词] 黄芩苷曰固体自乳化给药系统曰制备 [中图分类号]TQ461 [文献标识码]A [文章编号] 1673-7210渊2014冤07渊a冤-0096-04 Preparation ofBaicalin SolidSelf-emulsifying Granules 1 1 2银 GAO Yongyan CHENHaiwen LIANG Chaofeng 1.Department of Pharmacy, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510370, China; 2.Guangzhou General Pharmaceutical Industry Research Institute Co., Ltd., Guangdong Province, Guangzhou 510240, China [Abstract]ObjectiveTo studythe Baicalin Solid Self-emulsifying Granulespreparation process. Methods Investigated by solubility, drawing pseudo-ternary phase diagram, and L (3) orthogonal experimentwas given, to form a self-emul鄄9 3 sifying effect of self-emulsification time and particle size as indicator to select the best self-emulsifying prescription. Through the screeningofthe solidadsorbentmaterial, andthe determination of cumulative dissolution,the Baicalin sol鄄 id self-emulsifying particles prescription was screened. Results The optimization of the best prescription for oleic acid ethyl ester-Tween 80-PEG400was 2颐7颐6. Soluble starch and Baicalin S-SEDDS the mass ratio of 4颐1,dissolution was 102.89% in 45 min. Conclusion Baicalin S-SEDDS is easy to prepare and its quality is stable. The dissolution of BaicalinS-SEDDSisimproved. [Keywords] Baica