肠杆菌科细菌的分布及其产ESBL菌株的耐药性变迁.pdfVIP

肠杆菌科细菌的分布及其产ESBL菌株的耐药性变迁 黄狄娜+，邱卓婵，许韩波(普宁市人民医院药剂科，广东普宁515300) 中图分类号R378；R95文献标志码A 文章编号 1672—2124(2014)04—0325—03 摘要 目的：分析肠杆菌科细菌的分布及其产超广谱p．内酰胺酶(ESBL)菌株的耐药趋势，为临床合理选择抗茵药物提供依 菌科细菌分离率均在50％以上，尤以大肠杆菌和肺炎克雷伯菌感染分离率最高；肺炎克雷伯茵和大肠杆菌是产ESBL的代表菌 种；肠杆菌科细菌对氨苄西林及头孢曲松的耐药率普遍保持在较高水平，但对亚胺培南和哌拉西林／他唑巴坦的耐药率较低；应用 的抗茵药物主要为加酶抑制剂和第三代头孢菌素。结论：该院肠杆菌科产ESBL茵的耐药性在四个季度间无明显差异；ESBL介 导的细菌耐药性复杂而难治，必须长期严密地监测产ESBL菌情况，合理采取干预措施，遏制产ESBL茵的流行。 关键词肠杆菌科细菌；超广都一内酰胺酶；耐药性 Distributionof ResistanceofIts Strains Enterobacteriaceaeand Drug ESBLs—producing HUANG Di-na，QIUZhuo—chan，XU Han—bo(Dept．ofPharmacy，PuningMunicipalPeople’S dong 515300，China) Puning ABSTRACT thedistributionofenterobacteriaceaeandthe ofthe of OBJECTIVE：To resistanceESBL— analyze tendencydrug for strainsinenterobacteriaceaeSOasto referencesclinicalrationalchoiceof producing provide strainsofenterobacteriaceaeisolated 2013andthe strainsinenterobacteriaceaewere sta-- clinically during ESBL·-producing analyzed detectionrateofenterobacteriaceaeinour wasover EscherichialcoliandKlebsiella tistically．RESULTS：The hospital 50％，with thelistintermsofdetectionrate．K andEcoliwerethe strains．En— pneumoniaetopping pneumonia representativeESBL-producing with terobacteriaceaewas resistantto andceftriaxonelowresistanceratesto and tazobac— yet imipenem highly ampicillin piperacillin tam．Theantibioticsused were inhibitorsand