卵巢上皮癌中MDR1与CA125表达预测化疗效果的价值.pdfVIP

辽蕴医荭2鲤8生!!且筮丝鲞笙!』期Ji!强些丛茧jz№婴照￡gQQ8：№4塑：麴垒11 ：!Q2l： ● 论著 ● 25表达预测 卵巢上皮癌中MDRl与CAl 化疗效果的价值 龙启芳钱志红 朱维培石怡珍张路杨晨 【摘要】目的研究MDRI在卵巢上皮癌中的表达及其在卵巢七皮癌诊疗方面的价值。方法 采用荧光定疑RT．PcR技术检测卵巢组织中MDRI基因的rnRNA含量，化学发光法检测术前及术 后每次化疗前m清CAl25水平，分析MDRl与CAl25及其半衰期的相关性。结果MDRI摹因在 卵巢卜皮癌、良性肿瘤、正常卵巢组织中的表达差异有统计学意义(Po．01)。34例卵巢上皮癌中， 2d例CAl25升高。MDRl表达与CAl25相关关系较弱。在34例卵巢上皮癌患者中，CAl25半衰 dVS．16 期长的MDRI的表达高于cAl25半衰期短者(25d)(Po．05)。结论检测MDRl表 达nIJ}}J以预测卵巢卜皮癌患者对化疗的近期疗效。 【关键词】 多药耐药基因；卵巢上皮癌；化学治疗 【中图分类号】R71l【文献标识码】A 【文章编号】0253—3685(2008)11—1091—03 PredictivevalueofMDRlandCAl25 in canoBr under LoNG expressionovarianpatientschemotherapy Obstetricsand a1．Departmentof Q／Ja-g，gANZhihong，ZHUWeipei，et Gynecology，Affiliated Second 210000，CHINA Hospital，SoochowUniversity，Suzhou To the valueofMDRlandCAl25 inovarian [Abstract]Objectivestudypredictive expression canccr under The ofMDRlinovaries of34 patientschemotherapy．Methodsexpressions specimens withovariancancerweredetectedwithfluorescent reverse patients quantitationtranscription- chainreaction．SerumCAl25levelsweremeasuredbeforeandafter intervention polymerase surgical andbeforeeach chemoluminescencemethod．ResultsⅣⅡ)Rlwere chemotherapyby expressions different3 ofovariancances，variestumorsandnormalcontrolcases significantlyamonggroups benign with (P0．01)．()f34 ovariancancer，24caseshadelevatedserumCAl25(≥35U／m1)．The patients ofMDRl andtheserumCAl25levelswasnotremarkable．In34 with correlation