P-gp、GST-π和TOPO-Ⅱ在乳腺癌原发灶和复发灶中的表达.pdfVIP

·988‘ 210009 南京 江苏省肿瘤医院普外科姚宇锋，唐金海1，秦建伟 【摘要】 共同表达的病例数在原发灶中为13例，在复发灶中有19例。结论乳腺癌原发灶与复发灶中多种耐药基因蛋白表达存在明 显差异，复发灶中耐药基因蛋白表达更高，应引起临床重视。 【关键词】乳腺肿瘤；复发；多药耐药；P-糖蛋白 中图分类号：R737．9文献标识码：A 文章编号：1009—0460(2011)1l一0988—03 of breastcanceranditsrecurrentfocuses P-gP。GST-订，TOPO-Ⅱinprimary Expression YAO General Cancer fin—hai，QlNJian—wei．Departmentof Surgery，Jiangsu Yu母ng．TANG 210009，China ring author：TANG Corresponding Jin—hal，E—mail：dr_fiszlyy@yahoo．corn．cn clinical breast To the andthe of significance 【Abstract】Objectiveinvestigateexpression p-印，GST一订，TOPO一Ⅱinprimary canceranditsrecurrentfocuses．MethodsFrom 2008toDecember recurrentbreastcancer weree13一 2010，55 January locally patients rolledinthis wasusedtodetectthe of in andrecurrence study．Immunohistochemistryassay expressionP—gP，GST一竹，TOPO—IIprimary focusesof55breastcancer in Cancer The of inthe patientsJiangsu Hospital．ResultsexpressionsP—gP，GST-盯，TOPO—IIprimary breastcanceranditsrecurrentfocuseswere of inthe 63．6％，34．5％，45．5％and90．9％，41．8％，40．O％．The P—gP expression recurrentfocuseswas thanthatinthe breastcancer．Nineteen resistantintherecur- hJ【gher primary patientsexpressedmuhidruggenes There for P— rent 13 didinthe breastcancer．Conclusionare differencesthe of foc