西妥昔单抗致大疱性药疹及口腔黏膜损害.pdfVIP

．病例报告． 西妥昔单抗致大疱性药疹及口腔黏膜损害 江灏 陈英何菊英 【摘要】 1例56岁男性患者，因鼻咽癌行放疗+西妥昔单抗分子靶向治疗。首次静脉滴注西妥 昔单抗600mg，此后400nlrV次，1次／周。首次用药后第11天患者面部及胸背部出现红色斑丘疹，并 伴有脓疱，同时口腔黏膜红肿。给予氯雷他定抗过敏，呋喃西林溶液漱口。第4次用药开始将西妥昔 单抗剂量减为300mg，症状未见好转，患者出现口腔溃疡，舌体呈“地图”样改变，伴颈部皮肤糜烂。 加用碳酸氢钠溶液漱口并给予抗感染等治疗。共用药6次后停用西妥昔单抗。停药后约6周患者皮 肤、口腔黏膜损伤好转。 【关键词】 西妥昔单抗；大疱性药疹； 口腔黏膜损害 Bullous andoralmucosal inducedcetuximabHao JIANG4，CHEN eruption injury by Hng，HE Medical Ju—ying．+DepartmentofPharmacy，SouthwestHospital，ThirdMilitary University，Chongqing 400038．C讫ina Medical author：HEJu—ying，DepartmentofPharmacy，SouthwestHospital，ThirdMilitary Corresponding University，Chongqing400038，China，Email：hejuyin995@126．corn manreceiveda cetuximabmolecular for 【Abstract】A56一year—old radiotherapyplus targetedtherapy carcinoma．HereceivedanIVinfusionofcetuximab600 first then400 nasopharyngeal mg time，and mg first and his onceaweek．Elevenafterthe macules on days medication，red pustulesappearedface，chest andback．Hisoralnmcosawasredandswollenatthesametime．Loratadineandfurancilinsolutionwere for treatmentand doseofcetuximabdecreasedto 300 onthe4th givenanti—allergic gargle．The mg in in the werenot ulcers medication，but symptoms improved．Hedeveloped mouth，map—likechanges skinerosioninneck．A withsodium solutionandanti—infective corporalinguae，and gargle hydrocarbonate were waswithdrawnafter6 timesofmedication．About6 weeksafter therapygiven．Cetuximab