玻璃体腔注射avastin治疗视网膜分支静脉阻塞继发黄斑水肿疗效观察.pdfVIP

眼科研究2010年 1月第 28卷第 1期 · 79 · 临 床 研 究 · 玻璃体腔注射 avastin治疗视网膜分支静脉阻塞 继发黄斑水肿疗效观察 钱 彤 黎晓新 尹 虹 梁建宏 齐慧君 于文贞 Theclinicalstudyonintravitreousinjectionofavastinformacularedema inducedbybranch retinalveinocclusion QianTong，LiXiaoxin，YinHong，LiangJianhong，QiHu~un，YuWenzhen．DepartmentofOphthalmology， PekingUniversityPeople’sHospital，Beijing100044，China Abstract Background Branchretinalveinocclusion (BRVO)oftenleadstomacularedemaastheresultofelevating intravitrealVEGF level，andavastin，aanti—VEGF drug，show a good effectivenessonmacularedema secondary toBRVO． 0bjective ThisstudyattemptstoevaluatetheclinicalefficacyofavastinonmacularedemainducedbyBRVO． Methods Thisisaretrospectivecase—observationstudy．Theclinicaldataof39eyesfrom 39patientswithmacularedemainducedbyBRVO wereincludedinthisanalysis．Allofthepatientsreceivedintravitrealinjectionof1．25mg(0．05mL)avastinwithoutotherany therapypriortotheinjectionofavastin．ThisprocedurefollowedtheDeclarationofHelsinki，andwritteninformedconsentwas obtainedrfom all the patientsbefore and initialofany management．Clinicalindexes included best—corrected visual acuity (BCVA)，slit—lampexamination，intraocularpressureandstereoscopicbiomicroscopyexaminationbeforeinjectionand3，6and12 weeksafterinitialinjection．Opticalcoherencetomography (OCT)，fundusphotography，fluoresceinfundusangiography(FFA) wereperformedpriortoinjectionand6，12weeksafterinitialinjection．Thefollow—upperiodwas3—20months． Results The meanBCVAwassignificantlyimprovedat3，6，12weeksafterinjectionincomparisonwithbeforeinjection (t= 一6．039， 一 6．182，一4．189，allP=0．000)．ThemeanCMTshowedastatisticallysignificantlydeclineat6，12weeksafterinjectionin comparisonwithbeforeinjection(t=8．684，5．019，allP=0．000)．Noocularorsystemicadverseeventswerefounda