药代动力学中参数种间转化.pdfVIP

大连化学物理研究所药用资源开发组 药代动力学参数的种间放大 Pharmacokinetics and interspecies scaling 吴敬敬 Lab of Pharmaceutical Resource Discovery Dalian Institute of Chemical Physics, the Chinese Academy of Sciences Sep 28th, 2009 大连化学物理研究所药用资源开发组 Outline Pharmacokinetics Interspecies scaling – Volume of distribution • Methods of prediction of volume of distribution in humans – Clearance • Methods of prediction of clearance in humans • Limitations of allometry used i