抑郁症研究的动物模型.pptVIP

抑郁症研究的动物模型 基础01级 陈瑶瑶 I am depressed. Me too. Why we need animal models? The sorts of animal models. The future development of animal models. The uses of animal models Antidepressants screening. Mechanism studying 神经生化功能改变模型 应激模型 条件性饲养模型 基因工程动物模型 获得性无助模型 (learned helpless) 慢性温和应激模型 (chronic mild stress) 行为绝望模型 (behavioral despair) Gene-engineering mice Conventional transgenic mice Conditional gene-targeting methods Antisense targeting 展望 实验动物模型是研究抑郁症必不可少的工具。随着基因工程技术的出现，实验模型的可操作性和多样性都大大改善了。虽然转基因技术仍存在很多问题，但其仍有着光明的前景。 Reference ___________________________________________________________________________________________ 1．Janne Gr?nli a,., Robert Murison b,d, Bj?rn Bjorvatn c,d, Eli S?rensen a, Chiara M. Portas a, Reidun Ursin a,d ，Chronic mild stress affects sucrose intake and sleep in rats，Behavioural Brain Research 150 (2004) 139–147 2．John F. Cryan, Daniel Hoyer, and Athina Markou，Withdrawal from Chronic Amphetamine Induces Depressive-Like Behavioral Effects in Rodents，BIOL PSYCHIATRY 2003;54:49–58 3．Andrew Harkin*, John P. Kelly, Brian E. Leonard，A review of the relevance and validity of olfactory bulbectomy as a model of depression，Clinical Neuroscience Research 3 (2003) 253–262 4. Vijayakumar Mavanjia,b, Subimal Dattaa,*，Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood，Neuroscience Letters 330 (2002) 119–121 5. Ruth E. Grahn a,*, S.E. Hammack a, M.J. Will b, K.A. O’Connor a, T. Deak c,P.D. Sparks a, L.R. Watkins a, S.F. Maier a, Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats, Behavioural Brain Research 134 (2002) 387_/392 6. Peter Gassa,*, Holger M. Reichardtb, Tatyana Strekalovaa, Fritz Henna, Francois Troncheb, Mice with targeted mutations of glucocortico