The molecular mechanisms of Yang Wei Kang Liu powder on anticancer and reducing chemotherapy side-effect in combination with chemotherapy.pdfVIP

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The molecular mechanisms of Yang Wei Kang Liu powder on anticancer and reducing chemotherapy side-effect in combination with chemotherapy.pdf

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The molecular mechanisms of Yang Wei Kang Liu powder on anticancer and reducing chemotherapy side-effect in combination with chemotherapy.pdf

ThemolecularmechanismsofYangW eiKangLiu powderonanticancerandreducingchemotherapy side-- GuizhiSun，ZhikuiWu，JinyuLu，WenpingLu，XunWang DepartmentofOncology，Guang’anmenHospital，ChinaAcademyofChineseMedicalSciences，Beijing100053 China Received：31January2010／Revised：20February2010／Accepted：25April2010 @Springer-VerlagBerlinHeidelberg2010 Abstract Objective：WestudiedlhemolecularmechanismsofYangWeiKangLiuPower(YWKL，{raditionalChinese medicinefornourishingstomachandanticancer1onanticancerandreducingchemotherapyside—effeclincombinationwith chemotherapy．Methods：615pre．cancermousemodelofYWKLfor 0daysandCTX 1time，semi-quantitativereverse transcription—polymerasechainreaction(RT-PCR)todetectbonemarrowgranulocyte—macrophagecolony—stimulatingfactor (GM．CSF)qeneandcancerproto-oncogeneBc1．2，c-mycexpression尺esults：YWKLincombinationwithchemotherapy couldobviouslypromotedtheexpressionofGM—CSFgeneandinhibitedlheexpressionofBcl一2andc-myconcogenesof FC615mice．Conclusio，，Themolecularmechanismsofanticancerandreducingchemotherapyside—effecfofYWKLin combinationwithchemotherapyarelopromotelheexpressionofGM—CSFgeneandInhibil{heexpressionofBcl一2andc-myc oncogenes． Keywords YangWeiKangLiupowder；granulocytemacrophagecolony-stimulatingfactor(GM·CSF)；Bcl_2oncogene c-myconcogene Gastriccancerisakindofcommontumor，withhigh andultimatelypreventtumorrecurrenceandmetastasis incidenceandmortalityrates．Symptomsofearlygastric isalwaysthehotspotoftheworld’sm edicalresearch． cancerarenotobvious，andpatientsoftheclinicaldiag— Inrecentyears，studieshaveshownthat：Comparedwith nosisaremostlyadvanced．Onlyabout50％ ofthepatients thesimply treatmentofW estern medicineorChinese canbecuredbyradicalsurgicalresection．Ifthecancer medicine．theem cacyofthecombinationofChineseand cellsinfiltratedmuscularlayer，thoughhavingbeen re— W esternmedicine(radiotherapyandchemot