广东省普通人群非酒性脂肪性肝病患病率的流行病学调查.docVIP

广东省普通人群非酒精性脂肪性肝病患病率的流行病学调查 周永健1，3 李瑜元1 ,聂玉强1 马金香2 石胜利1 　　广州市第一人民医院消化内科1（510180） 广州医学院预防医学系2 广州市南沙中心医院消化内科3 背景：非酒精性脂肪性肝病（nonalcoholic fatty liver disease, NAFLD）与遗传、环境密切相关，广东省有其独特的经济文化特点，目前尚无该地区NAFLD的发病情况及其特点的系统报告。目的：调查广东省人群NAFLD的患病率及其主要危险因素。方法：采用多阶段分层随机整群抽样方法，选择广东省内6个城乡居民点，对7岁以上整体人群进行问卷调查、体检、实验室和腹部B超检查。结果：受调查的广东省3543人中，NAFLD患者530例，患病率为15.0%，其中男性NAFLD的患病率显著低于女性（13.0%对16.1%，P0.05）。城市人群患病率显著高于农村（20.3%对11.1%，P0.001）。按地区、年龄、性别标准化后，广东省成人NAFLD的患病率为11.7%。无论男女，NAFLD的患病率随年龄增长而增加，60~70岁患病率达到峰值（26.9%）。多因素Logistic回归分析显示男性、城市居住、文化程度低、高血压、肥胖、腰臀比、腰围以及血清三酰甘油和空腹血糖升高是NALFD的危险因素。结论：广东省NAFLD的患病率较高，与肥胖及其相关的多元代谢紊乱的关系密切。 关键词 非酒精性脂肪性肝病；流行病学；患病率；危险因素 Epidemiological Survey on Prevalence of Nonalcoholic Fatty Liver Disease in a General Population of Guangdong Province ZHOU Yongjian, LI Yuyuan, NIE Yuqiang, MA Jinxiang, LU Lungen, SHI Shengli. Department of Gastroenterology and Hepatology, Guangzhou First Municipal People’s Hospital,Guangzhou (510180) Background: Nonalcoholic fatty liver disease (NAFLD) is closely related with heredity and environment. Guangdong province has its special economic cultural characteristics in China, the prevalence and characteristics of NAFLD in this area has not been reported yet. Aims: To investigate the prevalence and risk factors of NAFLD in Guangdong province. Methods: A cross-sectional survey with randomized multistage stratified cluster sampling of inhabitants over 7 years old in 6 urban and rural areas of Guangdong province was performed. Questionnaires, anthropometric measurements, biochemical tests and abdominal ultrasonography were carried out. Results: Among 3543 subjects, 530 (15.0%) were diagnosed as having NAFLD, the prevalence in male was markedly lower than that in female (13.0% vs. 16.1%, P0.05), the prevalence in urban was significantly higher than that in rural area (20.3% vs. 11.1%, P0.001). After adjustments for age, gender and residency, the standardized prevalence of NAFLD was 11.7%. The overall prevalence of NAFLD increased