寿胎丸对提高体外受精-胚胎移植临床妊娠率的影响_药学论文.docVIP

寿胎丸对提高体外受精-胚胎移植临床妊娠率的影响_药学论文 寿胎丸对提高体外受精-胚胎移植临床妊娠率的影响_药学论文 作者：许志芃,单志群,潘纪华,刘小婷 【摘要】 目的 观察寿胎丸加味对提高体外受精-胚胎移植(IVF-ET)临床妊娠率的影响。方法 将2001－2003年中山医科大学深圳泌尿外科医院试管婴儿生殖中心采用IVF-ET助孕术后的有随访条件者80例随机分为2组,治疗组40例,对照组40例,治疗组自胚胎移植后除常规肌注黄体酮外运用中医辨证辅助治疗,对照组仅常规肌注黄体酮,不予其他干预,对2组疗效进行观察和比较。结果 治疗组40例,妊娠23例,临床妊娠率57.5%,平均孕激素水平(22.45±1.31)μg/L,妊娠流产率13.0%。对照组40例,妊娠12例,临床妊娠率30.0%,平均孕激素水平(10.18±0.89)μg/L,妊娠流产率25.0%,2组临床妊娠率、平均孕激素水平、妊娠流产率差异有统计学意义(P＜0.05,P＜0.01,P＜0.05)。结论 运用寿胎丸为基础方辨证治疗对提高IVF-ET临床妊娠率、降低妊娠流产率疗效显著优于单纯用黄体酮治疗。 【关键词】 体外受精；胚胎移植；辨证论治；寿胎丸 Abstract：Objective To observe the effect of Shoutaiwan on improving clinical pregnancy rate of in vitro fertilization-embryo transfer (IVF-ET). Method Eighty people, who were easy to be followed up and pregnant with the assistant of IVF-ET by the tube-baby centre of Shenzhen Urology Surgical Hospital of Zhongshan Medical University from 2001 to 2003, were divided into two groups randomly with 40 people for each. Treatment group, after embryo transfer, were normally injected progesterone and auxiliary treated of traditional Chinese Medicine according to syndrome differentiation. The comparing group were only injected progesterone. The curative effect was observed and compared. Result In 40 cases of treatment group, 23 cases were pregnant, clinical pregnant rate was 57.5%, the average level of progesterone was (22.45±1.31)μg/L, pregnant abortion rate was 13.0%. In 40 cases of comparing group, 12 cases were pregnant, clinical pregnant rate was 30.0%, the average level of progesterone was (10.18±0.89)μg/L, pregnant abortion rate was 25%. There were significant differences in the clinical pregnant statistical rate, the average level of progesterone and pregnant abortion rate between the two groups. Conclusion It’s more effective that the syndrome differentiation method based on Shoutaiwan than progesterone treatment only in improving clinical pregnant rate and reducing pregnant abortion rate of IVF-ET. 　　Key words：in vitro fertilization；embryo transfer；syndrome di