术后感染患者血清可溶性CD14和E┐选择素的变化意义 _医学论文.docVIP

术后感染患者血清可溶性CD14和E┐选择素的变化意义 _医学论文 术后感染患者血清可溶性CD14和E┐选择素的变化意义 _医学论文 【关键词】 肿瘤坏死因子 关键词: 感染抗原，CD14E选择素肿瘤坏死因子 摘 要:目的 探讨术后并发严重感染患者血清E-选择素（E-SLT）和sCD14的变化情况及其与病情预后的关系. 方法 采用ELISA于术前和术后测定37例手术和30例健康志愿者血清E-SLT、sCD14及TNF-α的浓度. 结果 E-SLT水平在未并发感染组于术后1d开始增高，术后3d达高峰（151±12）μg#12539L-1 ，4d后开始下降，至25d接近正常水平（40±10）μg#12539L-1 在并发严重感染组E-SLT水平于术后1d开始增高（68±9）μg#12539L-1 ，至术后25d时仍处于高水平状态（328±54）μg#12539L-1 .sCD14水平在未并发感染组于术后1d开始增高，4d后开始下降，至25d接近正常水平（1.03±0.16）mg#12539L-1 在并发严重感染组sCD14水平于术后1d开始增高，至术后25d仍处于高水平状态（2.63±0.82）mg#12539L-1 .sCD14与TNF-α者间的相关系数为r=0.896，0.05. 结论 sCD14和TNF-α在术后并发严重感染的早期病理过程中起着重要的作用，sCD14与早期感染密切相关E-选择素可能在感染病理变化过程的后期起着重要的作用，与感染严重程度相关.E-SLT和sCD14是反映术后并发感染病情变化和预后的可靠指标. 　　Keywords:infectionantigens，CD14E-selectintumor necrosis factor 　　Abstract:AIM To investigate the changes in serum levels of E-selectin，soluble CD14（sCD14）and TNF-α，as well as their relationship between infection and prognosis in postop-erative patients complicated by severe infection.METHODS Serum E-selectin and sCD14and TNF-αlevels in37post-operative patients and30controls ones were measured by ELISA before and after operation.RESULTS The level of E-selection in patients without infection began to rise on d1after the operation and reached the hightest level ［（151±12）μg#12539L-1 ］on d3.Then it started to reduce on d4till the d25，it was close to normal ［（40±10）μg#12539L-1 ］，while in pa-tients with severe infection，the level of E-selection began to go up d1after the operation ［（68±9）μg#12539L -1 ］，and re-mained high ［（328±54）μg#12539L-1 ］even on d25after the op-eration.The level of sCD14in patients without infection be-gan to increase d1after the operation and started to reduce on d4till the d25it became close to normal ［（1.03±0.16）mg#12539L-1 ］while in patients with severe infection，the level of sCD14began to go up and reached the highest level ［（2.63±0.82）mg#12539L-1 ］on d25.The correlation coefficient（r）in the serum levels of sCD14and TNF-αwere0.896，0.05.CONCLUSION sCD14and TNF-αmay play an im