杏丁注射液对兔严重心肌挫伤的治疗作用_医学论文.docVIP

杏丁注射液对兔严重心肌挫伤的治疗作用_医学论文 杏丁注射液对兔严重心肌挫伤的治疗作用_医学论文 作者：牛义民，刘达兴，刘日辉，周继红 【关键词】 心脏损伤 Experimental studies on treatment of severe myocardial contusion with Xingding injection in rabbits 　　【Abstract】 AIM: To explore the role of Xingding injection (XDI), an injection made of traditional Chinese medicinal herbs, in the treatment of myocardial contusion in rabbits. METHODS: Thirty rabbits were randomly divided into three groups: control group with falseimpact (control group, n=10), severe myocardial contusion group (MC group, n=10) and XDI treatment group (XDI group, n=10). The models of rabbit with severe myocardial contusion were made by BIMII Horizontal Bioimpact Machine. At 5 min before impact and 5 min, 30 min, 2, 4, 8 and 24 h after impact, blood samples were taken from common carotid artery of rabbits in each group to measure the concentrations of plasma thromboxane A2 (TXA2) and prostacyclin (PGI2) by radioimmunoprecipitation. At the end of the experiment, the heart of one rabbit from each group was harvested to observe the microstructural changes and 2 hearts were randomly taken from each group to observe ultrastructural changes. RESULTS: The concentrations of plasma PGI2 had a distinct fallingoff while the contents of plasma TXA2 were significantly higher in the early period of severe myocardial contusion (at 4 h after myocardial contusion). The morphological injuries of myocardial tissues were severe. With XDI, the reduction of the concentrations of plasma PGI2 and the increase of the contents of plasma TXA2 were significantly relieved. The morphological injuries of myocardial tissues were obviously lessened. CONCLUSION: Xingding injection can improve the reduction of the concentrations of plasma PGI2 and the increase of the contents of plasma TXA2 in the early period of severe myocardial contusion, which may concentrate to its therapeutic effect on severe myocardial contusion. 　　【Keywords】 heart injuries contusions PGI2 TXA2 Xingding injection 　　【摘要】 目的： 探讨杏丁注射液对心