大鼠长期毒性试验质量控制探讨_许迪.pdfVIP

20 10 1 Janu ary, 20 10 20 1 CH IN ESE JOU RNA L O F COM PARAT IVE M ED IC IN E V ol. 20 N o. 1 1 1 2 1 1 1 许 迪, 孔利佳, 杜佐华 , 周顺长 , 叶明霞, 熊美云 ( 11 , 4 30030; 21 , 430030) = , = ; ; = R-332 = A = 167 1-7856( 20 10) 01-006 1-03 Quality Control of Long-term Toxicity Test on Rat 1 1 2 1 1 1 XU D i, KONG L -i j ia , DU Zuo-hua , ZHOU Shun-chang , YE M ing-x ia , X IONG M e-i yun ( 11F acu lty of L abo ra to ry A nmi a l Sc ience, T ongjiM edical Co llege, Huazhong U niversity of Science and T echno logy, W uhan 4 30030, China; 21Departm ent of Pharm aco logy, T ongj iM edical Co llege, H uazhong U niversity of Sc ience and T echno logy, W uhan 430030, China) = Abstract H ow to contro l the qua lity o f long-te rm tox ic ity test on ra ts is very mi portan t. It includes the qua lity contro l before and during and after the exper mi ent. T he key thing is dose-design ing, w h ile the co re is prac tic ing acco rding to the good laboratory practice and the standard operating procedure, the m ost mi po rtant and d iff icu lt is to contro l the qua lity o f da ta- ana lysis and repo rt. = Key words Long-term tox ic ity test; Q ua lity contro l; R a t , , , , ; , ;