注意缺陷多动障碍在中国的分子遗传学研究进展.pdfVIP

• 194 • Shanghai Archives of Psychiatry, 2014, Vol. 26, No. 4 •Review• Advances in molecular genetic studies of attention deficit hyperactivity disorder in China Qian GAO1,2, Lu LIU1,2, Qiujin QIAN1,2*, Yufeng WANG1,2* Summary: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition in children worldwide that typically includes a combination of symptoms of inattention and hyperactivity/impulsivity. Genetic factors are believed to be important in the development and course of ADHD so many candidate genes studies and genome-wide association studies (GWAS) have been conducted in search of the genetic mechanisms that cause or influence the condition. This review provides an overview of gene- association and pharmacogenetic studies of ADHD from mainland China and elsewhere that use Han Chinese samples. To date, studies from China and elsewhere remain inconclusive so future studies need to consider alternative analytic techniques and test new biological hypotheses about the relationship of neurotransmission and neurodevelopment to the onset and course of this disabling condition. Keywords: ADHD, genetics, candidate gene studies, GWAS, China [Shanghai Arch Psychiatry. 2014; 26(4): 194-206. doi: /10.3969/j.issn.1002-0829.2014.04.003] 1. Introduction ADHD is a complex condition caused by the interac- Attention deficit hyperactivity disorder (ADHD) is a tion of genetic, social, and environmental factors.[8] highly prevalent childhood-onset neuropsychiatric Adoption and twin studies have helped disentangled condition, with an estimated worldwide-pooled