hUCMSCs并西格列汀对糖尿病大鼠肝脏蛋白激酶B表达影响_聂静.pdfVIP

DOI ：10.13362/j.qlyx201401010 网络出版时间：2014-01-15 10:55 # 26 # 2014 2 29 1 Med J Qilu , February 2014 , Vol 2. 9 , No .1 网络出版地址：/kcms/doi/10.13362/j.qlyx201401010.html doi :10 .13362/j .qlyx201401010 hUC MSCs B , ( , 266071) [ ] ( h UC MSCs) ( STZ) B( AKT) 32 ( 8 ) ( 24 ) , STZ (30 mg/ kg) ; hUC MS Cs h UC MSCs ( ) ,h UC MS Cs 15 h UC MS Cs ; 10 mg/ ( kg #d) 10 , 1 5 h UC MS Cs ; 10 , , AKT h UC MSCs AKT , , ( H = 25.085 ,q = 3 .211 ~ 9 .275 ,P 0 .05) , h UC MSCs ( q = 5.967 , P 0 0. 5) h UC MSCs AKT ,h UC MSCs [ ] ; ; ; ; [ ] R587 .1 [ ] A [ ] 1008 0341(2014) 01 0026 03 THE EFFECT OF hUCMSCs COMBI NED WI TH SITAGLI PTI N ON EXPRESSI ON OF PROTEI N KI NASE B I N LI VER OF RATS WITH DI ABETES NI E Jing , WA N G Yancgang ( Depart ment of Endocrinology , The Affiliated Hospital of Qingdao Universit y Medical College , Qingdao 266071 , China) [ ABSTRACT Obj ecti ve To explor e t he influence of intravenous h UCMSCs co mbined wit h sitagliptin on expression of pr o tein kinase B( PKB) in liver tissue of rats wit h diabetesinduced by streptozotoci n ( STZ) . Met hods Thirty t wo rats wer e divided int o nor mal contr ol group ( eight rat s) and diabetes gr oup ( 24 rats) i n rando m . A diabetic model was created in diabetes group by high glucose and hig h fat diet and intr aperitoneal injection of a s mall dose of STZ ( 30 mg/ kg) . Upon co mpletion of t he model , the r ats wit h diabet es were evenly r ando mized to diabetes control gr oup , hUCMSCs gr oup and co mbi ned gr oup ( hUC MSCs + sit aglip tin) . The rats in h UC MSC