交联聚天冬氨酸基聚离子胶束的制备与表征.pdfVIP

2009年第67卷 化学学报 、，01．67．2009 第8期，857～862 ACTACHIMICASmICA No．8．857～862 ·研究论文· 交联聚天冬氨酸基聚离子胶束的制备与表征 刘晓英 陈伟 洪震牛 (复旦大学附属华山医院神经病学研究所上海200040) 互作用，在磷酸缓冲液中形成了以PEG为壳、聚天冬氨酸复合物为核的聚离子胶束．研究发现。该聚离子胶束粒子呈 球形，粒径约为70衄，且粒径分布较窄．然而，体系的稳定性受溶液的pH和盐离子强度影响较大．通过戊二醛交联 PEG-g-PDEA中的伯胺可以有效提高该聚离子胶束对pH和盐离子强度的稳定性． 关键词聚离子胶柬；聚天冬氨酸；聚琥珀酰亚胺；交联；核壳结构 andCharacterizationofCross—linkedMicelles Preparation Polyion Formed rticAcidDerivates byPolyaspa Chen，Wei Liu，Xiaoying Hong，Zhen簟 Middle University,12 (InstituteofNeurology，HuashanHospital,Fudan WulumuqiRoaa,Shanghai200040) AbstractTwokindsof and polyasparticacid(PAsp)derivates，i．e．PEG-g-PAspPEG-g-PDEA，werepre- the reactionof alkaline paredthroughring·opening polysuccinimidebyCH30-PEG-NH2，followedby hy— and theelectrostaticinteractionbetween micelles drolysisaminolysis，respectively．Utilizing them，polyion withPEGshelland corewereformedin buffer．Theresultsshowedthatthe PAspcomplex phosphate poly- ionmicellesare withall diameterofabout70 thesizedistributionisnarrow． spherical average nm，and of micelleswas affectedandionic of However，thestabilitypolyion strongly bypH strength．Crosslinking in could aminecontained the of prima