肾脏发育中信号通路的调控作用.pdfVIP

Hereditas (Beijing) 2015 年 1 月, 37(1): 1 ―7 综 述 肾脏发育中信号通路的调控作用 1,2 1,2 2 1,2 邱晓 ，韦荣飞 ，张令强 ，贺福初 1.清华大学生命科学学院，北京 100089； 2. 军事医学科学院放射与辐射医学研究所，蛋白质组学国家重点实验室，北京 100850 摘要:肾脏发育是一个复杂的过程，需要在输尿管芽细胞和基质细胞相互诱导下，引起细胞生长、增殖、分化， 从而产生肾单位及各种管状结构，最终发育为成熟的肾脏。在肾脏发育过程中，GDNF/Ret 、Wnt 、BMP 等一 系列信号通路参与了发育的调控过程。这些信号通路在肾脏发育的不同阶段或不同位置发挥着重要的调控作 用，并且通路之间存在相互的调控，从而形成了一个复杂而精细的调控网络，保证了肾脏的正常发育。文章概括了 肾脏发育的过程，总结了肾脏发育过程中相关信号通路对肾脏发育的调控作用以及信号通路之间的相互调控。 肾脏发育；GDNF/Ret ；Wnt ；BMP ；FGF ；Notch 关键词: The roles of signaling pathways in regulating kidney development 1,2 1,2 2 1,2 Xiao Qiu , Rongfei Wei , Lingqiang Zhang , Fuchu He 1. School of Life Sciences, Tsinghua University, Beijing 100089, China; 2. State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Be ijing 100850, China Abstract: The development of mammalian kidney is a complex process. The reciprocal inductive interac- tions between epithelial cells and metanephric mesenchymal cells determine cell fates including proliferation, growth, apoptosis, and eventually contribute to the formation of an intact kidney. Multiple signaling pathways, including the GDNF/Ret, Wnt and BMP signaling pathways, have been shown to regulate the development of kidney. A myriad of signaling pathways and their cross-talks form a precise spatiotemporal regulatory network, which ensures the kidney to be properly organized. In this review, we summarize the physiological process of kidney development as well as the involved signaling pathways and their interplay. Keywords: kidney development; GDNF/Ret; Wnt; BMP; FGF; Notch 肾脏是体内重要的器官，能够维持水分平衡、 来源于输尿管芽及其周围的基质细胞。这两种细胞 酸碱度平衡以及排出代谢产物。虽然肾脏内有包括 在多条信号通路的调控下，经过复杂的发育过程， 肾小球以及收集管等很多特化的结构