Clustering and Classification In Gene Expression Data.pptVIP

Clustering and Classification In Gene Expression Data Carlo Colantuoni ccolantu@jhsph.edu Clustering Clustering organizes things that are close into groups. What does it mean for two genes to be close? What does it mean for two samples to be close? Once we know this, how do we define groups? Hierarchical and K-Means Clustering Distance We need a mathematical definition of distance between two points What are points? If each gene is a point, what is the mathematical definition of a point? Points Gene1= (E11, E12, …, E1N)’ Gene2= (E21, E22, …, E2N)’ Sample1= (E11, E21, …, EG1)’ Sample2= (