Post-Transcriptional Gene Silencing (PTGS).pptVIP

* DCL– dicer-like nuclease in plants; Drosha-nuclease that process pre-MiRNAs in animals. MicroRNAs can inhibit binding of a translation initiation factor in animals. * Millar, A.A. and P.M. Waterhouse (2005) Plant and animal microRNAs: similarities and differences. Functional Integrative Genomics 5: 129-135 Post-Transcriptional Gene Silencing (PTGS) Also called RNA interference or RNAi Process results in down-regulation of a gene at the RNA level (i.e., after transcription) There is also gene silencing at the transcriptional level (TGS) Examples: transposons, retroviral genes, heteroch