Bone marrow stromal cells use TGF-βto suppress资 料.pdf

Bone marrow stromal cells use TGF-β to suppress allergic responses in a mouse model of ragweed- induced asthma a,b,1 c c c d c Krisztian Nemeth , Andrea Keane-Myers , Jared M. Brown , Dean D. Metcalfe , James D. Gorham , Virgilio G. Bundoc , Marcus G. Hodgesc e c b a,1 , Ivett Jelinek , Satish Madala , Sarolta Karpati , and Eva Mezey aNational Institute of Dental and Craniofacial Research, Craniofacial and Skeletal Diseases Branch, National Institutes of Health, Bethesda, MD 20892; bDepartment of Dermato-Venereology and Dermato-Oncology, Semmelweis University, H-1085 Budapest, Hungary; cLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; dDepartment of Pathology and of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756; and eNational Cancer Institute, Experimental Immunology Branch, National Institutes of Health, Bethesda, MD 20892 Edited* by Susan E. Leeman, Boston University School of Medicine, Boston, MA, and approved January 22, 2010 (received for review September 18, 2009) Bone marrow stromal cells [BMSCs; also known as mesenchymal Results stem cells (MSCs)] effectively suppress inflammatory responses in Lung Pathology. Following ragweed (RW) challenge (for timing of acute graft-versus-host disease in humans and in a number of the events see Fig. 1), microscopic examination of the lungs showed disease models in mice. Many of the studies concluded that BMSC- minimal or no inflammation in mice sensitized with PBS solution driven immunomodulation is mediated by the suppression of pro-