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BIOMEDICAL CHROMATOGRAPHY Biomed. Chromatogr. 18: 820–825 (2004) Published online in Wiley InterScience (). 820 ORIGINAL RESEARCH C.-C. Wang et al. ORIGINAL RESEARCH DOI: 10.1002/bmc.395 Photolysis of NSAIDs. IV. Photoproducts of zomepirac determined by LC-ESI-MS 1 2 3 3 3 Ching-Chiung Wang, Fu-An Chen, Chih-Jui Chen, Su-Hui Chao and An-Bang Wu * 1Graduate Institute of Pharmacognosy Science, Pharmacy College, Taipei Medical University, Taipei 110, Taiwan, Republic of China 2Department of Pharmacy, Tajen Institute of Technology, Yen-pu 907, Pingtung, Taiwan, Republic of China 3Graduate Institute of Pharmaceutical Sciences, Pharmacy College, Taipei Medical University, Taipei 110, Taiwan, Republic of China Received 14 November 2003; revised 5 March 2004; accepted 23 March 2004 ABSTRACT: A sample of 10 mM zomepirac in methanol was photo-irradiated with a Hanovia 200 W high-pressure quartz Hg lamp for 14 days. In total, four photoproducts were observed from the HPLC chromatogram. The preparative HPLC included an YMC-Pack Pro C column (250 × 20 mm i.d.), a mobile phase of CH CN–CH OH–1%HOAc (10:60:30, v/v/v), and UV detection 18 3 3 at 254 nm. The most probable structures of the four photoproducts were determined by LC-MS. Two major photoproducts were separated, and their structures were further confirmed by the spectroscopic methods. A reaction scheme of zomepirac was pro- posed that the photochemical reaction route