血浆同型半胱氨酸在缺血性脑血管疾病中的变化和意义_医学论文.docVIP

血浆同型半胱氨酸在缺血性脑血管疾病中的变化和意义_医学论文 血浆同型半胱氨酸在缺血性脑血管疾病中的变化和意义_医学论文 【摘要】 目的 探讨缺血性脑血管疾病患者血浆中同型半胱氨酸(homocystein, Hcy) 水平及临床意义。方法 以健康体检者100例作为正常对照组，将153例缺血性脑血管疾病患者按疾病分2组，A组：84例椎基底动脉供血不足患者，依据是否伴有动脉粥样硬化再分A1组（椎基底动脉供血不足伴有动脉粥样硬化），A2组（椎基底动脉供血不足不伴有动脉粥样硬化）；B组：69例脑血栓形成患者，依据是否伴有动脉粥样硬化再分为B1组（脑血栓形成组伴有动脉粥样硬化，B2组(脑血栓形成不伴有动脉粥样硬化），分析各组患者血清Hcy水平与缺血性脑血管疾病的关系。结果 缺血性脑血管疾病患者各组血浆Hcy水平均高于对照组A组中伴有动脉粥样硬化的患者(A1组)血清Hcy水平明显高于不伴有动脉粥样硬化患者（A2组），差异有统计学意义, P lt 0.05，在B组，尽管B1组患者血清Hcy水平均高于B2组，但差异无统计学意义, P＞0.05。结论 血浆Hcy 水平的升高与缺血性脑血管疾病发生发展正相关,与动脉粥样硬化关系更密切。 【关键词】 缺血性脑血管疾病 脑血栓形成 动脉粥样硬化 同型半胱氨酸 【Abstract】 Objective To investigate the plasm homocysteine level in different patients with ischaemic cerebral vascular disease and its clinical significance. Methods: 100 cases healthy individuals were nocmal controls 153 patients with ischaemic cerebral vascular disease were divided into 2 groups ,group A, 84 patients with vertebrovascular insufficiency cases according to vascular atherosclerosis, were divided into A1 (vertebrovascular insufficiency with vascular atherosclerosis )and A2 (vertebrovascular insufficiency without vascular atherosclerosis)；Groups B ,69 patients with cerebralthrombosis according to vascular atherosclerosis were divided into B1（with vascular atherosclerosis）and B2 group(without vascular atherosclerosis) . And then the interrelation between the homocysteine levels, the disease and accompanying diseases were analyzed. Results: The plasm homocysteine levels of all disease groups showed higher than the control group. Group A1 were obviously higher than Group A2. The changes of these markers were more significant (P lt 0. 05). Conclusions: The plasm homocysteine levels are related to the ischaemic cerebral vascular disease , especially for the atherosclerosis. 【Key words】 Ischaemic cerebral vascular disease vertebrovascular insufficiency Cerebralthrombosis Homocysteine 脑血管疾病是目前严重危害人类健康的主要疾病之一，已知的脑血管疾病的危险因子不能完全解释脑血管疾病的发生。同型半胱氨酸（homocysteine, Hcy）是一种含硫氨基酸，是蛋氨酸代谢的中间产物[1]。在正常人体内血浆Hcy 浓度大约为5-15μmol/L