食管鳞癌组织和淋巴结中Paxillin和survivin的表达及其意义_医学论文.docVIP

食管鳞癌组织和淋巴结中Paxillin和survivin的表达及其意义_医学论文 食管鳞癌组织和淋巴结中Paxillin和survivin的表达及其意义_医学论文 作者：王雷，平育敏，孟宪利，何明，白世祥，杜媛鲲【摘要】 目的研究Paxillin和survivin在食管鳞癌组织中的表达及其与食管鳞癌细胞发生发展与转移的关系。方法应用免疫组化SP法检测24例正常食管黏膜、94例食管鳞癌和83例淋巴结组织中survivin和Paxillin的表达情况。结果原发癌组织中Paxillin表达率与淋巴结转移(0.05)、浸润深度(0.01)和临床分期(0.01)等因素有关；原发癌组织中survivin与浸润深度有关(0.01)；原发癌组织和转移淋巴结组织中Paxillin和survivin表达率均高于无转移淋巴结组织(0.05)； Paxillin和survivin在淋巴结中表达成正相关性(0.05)。结论Paxillin和survivin在食管鳞癌组织和转移淋巴结中高表达，在食管鳞癌的发生发展过程中具有重要作用，可作为评价食管鳞癌生物学行为的指标。 【关键词】 食管鳞癌；Paxillin；survivin；免疫组织化学 　　　　Abstract：ObjectiveThe expression of Paxillin and survivin in esophageal carcinoma and to investigate the relationship between the expression of Paxillin， survivin and carcinogenesis and progression of esophageal carcinoma.MethodsPaxillin and Survivin expression were detected in 24 normal esophageal mucosa, 94 primary tumor tissues and 83 lymph nodes with SP immunohistochemistal method.ResultsThe positive expression rate of Paxillin had the relationship with invasive depth, clinical staging and metastasis of lymph node (0.05). survivin had the relationship with invasive depth (0.05) .The expression of Paxillin，survivin in positive lymph node was much higher than that in negative lymph node respectively(0.05). There was a positive relationship between Paxillin and survivin expression in this study (0.05).ConclusionPaxillin and survivin are over expressed in esophageal carcinoma.They play important roles in carcinogenesis and progression of esophageal carcinoma and can be used as valuable biomakers to evaluate biological characteristics in esophageal squamous cell carcinoma. 　　Key words：Esophageal squamous cell carcinoma Paxillin survivinImmunohistochemisty 　　0引言 　　桩蛋白(Paxillin)是最近发现的一种在局部黏附中起重要作用的细胞黏附分子，Paxillin表达的异常与肿瘤的发生有一定关系，阳性表达与肿瘤的侵袭转移相关[1]。survivin是凋亡抑制蛋白(Inhibitor of apoptosis proteins,IAPs)家族的成员,近年来研究表明,survivin具有强大的抗细胞凋亡以及促有丝分裂作用，与肿瘤的发生演变密切相关 [2,3]。Paxillin在食管鳞癌中的表达的研究未见报道。有关survivin蛋白在食管鳞癌中的表达，国内外研究较少且集中在癌组织中，对淋巴结中的研究未见报道。本文采用免疫组化SP法检测了survivin和Paxi