微波促进下 2-芳氧甲基苯并咪唑-1-乙酸衍生物的合成及生物活性研究.pdfVIP

2007 年第 27 卷 有 机 化 学 Vol. 27, 2007 第 9 期, 1116～1120 Chinese Journal of Organic Chemistry No. 9, 1116～1120 ·研究论文· 微波促进下 2-芳氧甲基苯并咪唑-1- 乙酸衍生物的合成及生物活性研究 魏太保 师海雄 张治仁 崔文辉 张有明* (西北师范大学化学化工学院 甘肃省高分子材料重点实验室 兰州 730070) 摘要 采用微波辐射和相转移催化技术, 在 K2CO3 存在下利用 PEG-400 作相转移催化剂, 经过 N-烷化、水解和酸化等 步骤合成了 10 种尚未见文献报道的 2-芳氧甲基苯并咪唑-1- 乙酸衍生物. 经元素分析, FT-IR, 1H NMR 和 13C NMR 确证 了其结构. 生物活性实验结果表明该系列化合物对小麦幼苗根系和芽的生长均有明显的调节活性. 关键词 微波促进合成; 2-芳氧甲基苯并咪唑-1- 乙酸; 生物活性; 相转移催化 Microwave Promoted Synthesis and Biology Activity of 2-Aryloxymethylbenzimidazole-1-acetic Acid Derivatives WEI, Tai-Bao SHI, Hai-Xiong ZHANG, Zhi-Ren CUI, Wen-Hui ZHANG, You-Ming* (College of Chemistry and Chemical Engineering, Gansu Key Laboratory of Polymer Materials, Northwest Normal University, Lanzhou 730070) Abstract Ten novel derivatives of 2-aryloxymethylbenzimidazole-1-acetic acid were synthesized by N-alkylation of 2-aryloxymethylbenzimidazoles with methyl chloroacetate under MWI and PTC conditions using PEG-400 as a phase transfer catalyst in the presence of potassium carbonate. All the products were 1 13 characterized by elemental analysis, FT-IR, H NMR and C NMR spectra. The preliminary biological ac- tivity tests show that all the compounds have obvious regulating activities for the growth of the wheat. Keywords microwave promoted synthesis; 2-aryloxymethylbenzimidazole-1-acetic acid; biology activity; phase transfer catalysis 苯并咪唑衍生物是一类具有多种生物活性的杂环 收率低、副产物多或后处理繁杂等不足之处[5]. 鉴于微 化合物, 具有抗心律不