a randomized controlled comparison of neuro-navigated unilateral vs sequential bilateral rtms for treatment resistant depression论文.pdfVIP

Abstracts / Brain Stimulation 8 (2015) 360 e377 365 NIBS is large inter- and intra-subject variability in NIBS-induced Conclusions: Using a novel TMS-EEG network mapping neuroplastic responses. We investigated (1) the reproducibility of approach, we provide evidence that efferent connectivity from neuroplastic responses induced by continuous theta-burst stimu- the PFC is reduced in people with schizophrenia. Importantly, this lation (cTBS) and (2) factors that can influence an individual’s deficit is specific to connectivity within gamma-band frequencies neuroplasticity response to cTBS. In 18 subjects, motor evoked and is related to impaired functional connectivity observed dur- potential (MEP) input-output (I/O) curves were obtained before and ing WM. after cTBS (3 stimuli at 50 Hz every 200 msec for 40 sec) and measures of physical activity levels, stress levels, and sleep patterns were obtained in three separate experimental sessions. MEP sup- 187 pression was observed following cTBS at the upper end of the IO curve (150 e 180% RMT). Significant linear relationships were A randomized controlled comparison of neuro-navigated evident between (1) cTBS-induced MEP suppression (probed at unilateral vs sequential bilateral rTMS for treatment resistant 150% RMT) and perceived stress and (2) cTBS-induced MEP sup- depression D.M. Blumberger a,b,c d c a,b pression (probed at the stimulus intensity that evoked a MEP w50%