Neonatal Brain Development assessed by new quantitative .pptVIP

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2018-03-26 发布于江西
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Neonatal Brain Development assessed by new quantitative .ppt

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Neonatal Brain Development assessed by new quantitative .ppt

* Neonatal Brain Development assessed by new quantitative Analysis of 3-Tesla MRI and DTI 1,2G Gerig, 2Pierre Fillard, 2M Prastawa, 3W Lin, 1John Gilmore, Departments of 1Psychiatry, 2Computer Science, 3Radiology University of North Carolina, Chapel Hill,NC 27614, USA, gerig@ / /~gerig SUMMARY Structural MRI It is feasible to study brain development in unsedated newborns using 3T MRI Study will likely provide a vastly improved understanding of early brain development and its relationship to neuropsychiatric disorders. Novelty: Tissue model for segmentation of myelinated/nonmyel. white matter. Novelty: Use of tractography for complex regions of interest analysis. CONCLUSIONS Building of Atlas Template Research: Quantitative MRI to study unsedated newborns at risk for neurodevelopmental disorders. Clinical Study: 120 newborns to e brecruited at UNC, age at MRI about 2 weeks Motivation: Early detection of abnormalities ? Possibility for early intervention and therapy. Imaging: High field (3T Siemens Allegra), high resolution (T1 1mm3, FSE 0.9x0.9x3mm3), high-speed imaging (12’ for T1, FSE and DTI). Preliminary Study: 20 normal neonates (10 males, 10 females) Age 16 ± 4 days Siemens 3T head-only scanner Neonates were fed prior to scanning, swaddled, fitted with ear protection and had their heads fixed in a vac-fix device A pulse oximeter was monitored by a physician or research nurse Most neonates slept during the scan Motion-free scans in 13-15 infants Conte Center: Total of 120 infants T1 3D MPRage 1x1x1 mm3 FSE T2w 1x1x3 mm3 FSE PDw 1x1x3 mm3 Here Text Here Text Template MRI white matter csf gray matter Tissue Probability Maps Neonate Adult Approach: Atlas-moderated EM segmentation (cf. Leemput and Warfield) Tissue intensity model for white matter (non-myelinated and myelinated wm form bimodal distribution) (cf. Cocosco, Prastawa) Challenge: Very low CNR, heterogeneous tissue, early myelination regions, reverse contrast wm/gm. Standard brain tissue segmentation f