陶瓷膜表面接枝POEGMA分子刷对蛋白质截留的影响.pdfVIP

陶瓷膜表面接枝POEGMA 分子刷对蛋白质截留的影响* 1 1 1 1 何华婷 ，石风强 ，景文珩 ，邢卫红 （1 南京工业大学化学化工学院材料化学工程国家重点实验室，江苏 南京，210009 ） 摘要：采用表面引发原子转移自由基聚合（ATRP ）法将聚甲氧基聚乙二醇甲基丙烯酸酯分子刷（POEGMA ） 接枝到陶瓷膜表面以提高其抗蛋白吸附能力。考察了接枝时间对片式陶瓷膜过滤性能的影响，随着接枝时 间的增加，膜的纯水通量降低，牛血清白蛋白水溶液的截留率升高，当接枝时间由0h 增加到3.5h 时，截 留率由10%升高到60% 。在此基础上，对管式陶瓷超滤膜进行了接枝改性，改性后的膜孔径由7.4nm 减小 到2.9nm ，该膜对杆菌肽锌溶液的截留率由10%升高到75% 。 关键词：表面接枝；陶瓷膜；聚合物分子刷；抗蛋白吸附 中图分类号：TQ 028.8 文献标识码：A Effect of protein rejection on ceramic membranes modified with POEGMA brushes 1 1 1 1 He Huating , Shi Fengqiang , Jing Wenheng , Xing Weihong (1 State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology , Nanjing 210009, Jiangsu, China;) Abstract ：Ploy(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) brushes were grafted from ceramic membranes surfaces via surface-initiated atom transfer radical polymerization (ATRP) to inhibit protein adsorption of the membranes. The influence of reaction time on the performances of the plate ceramic membranes was studied. With the extension of reaction time , pure water flux of the membranes was reducing and the rejection of bovine serum albumin(BSA) was increasing. When reaction time from 0h rose to 3h, the rejection was increased from 10% to 60%. On this basis, the tube ceramic membrane was modified with POEGMA brushes. The mean pore size of the modified membrane was reduced from 7.4 nm to 2.9nm and the zinc bacitracin rejection was increased from 10% to 75%. Key words ：surface grafting；ceramic membrane ；polymer brushes ；protein-resistant 引 言 在蛋白质的分离与纯化过程中，膜分离技术作为一种新型分离技术，由于具有能耗低、