环烷基咪唑啉季铵盐杀菌机理的初步探讨.pdfVIP

天津 2010 全国水处理技术研讨会论文集 ∗ 环烷基咪唑啉季铵盐杀菌机理的初步探讨 石顺存 龙云飞 刘志强 喻娟娟 邓春凤 康玉佳 （湖南科技大学化学化工学院，湘潭 411201 ） CWTC-10-012 [摘要] 为探讨环烷基咪唑啉季铵盐药剂的杀菌机理，先后进行了体外抑菌实验及其与 DNA 相互作用的实验等。结果表明，该药剂具有较广谱的杀菌抑菌作用，检品小白鼠一次灌胃 LD50 为 3.07 g/kg，其与 DNA 相互作用后体系的共振光散射 （RLS ）强度明显增强，且 RLS 强度随 DNA 浓度的增大而增强。其主要杀菌机理是：环烷基咪唑啉季铵盐与 DNA 结合，引起 DNA 突变，从 而导致细菌死亡。 [关键词] 咪唑啉；咪唑啉季铵盐；环烷酸；杀菌剂；杀菌机理 Study of Naphthenic Imidazolinyl-Quaternary-Ammonium-Salt on Bactericidal Mechanism Shi shuncun, Long yunfei, Liu zhiqiang, Yu juanjuan, Deng chunfeng, Kang yujia (School of Chemistry Chemical Engineering, Hunan University of Science Technology, Xiangtan 411201, China) Abstract ：To explore naphthenic imidazolinyl-quaternary-ammonium-salt(NIS) on the bactericidal mechanism, the experiments were conducted successively on antibacterial test in vitro, interaction between NIS and DNA. Results were shown that NIS is with a broad spectrum of bactericidal and antimicrobial effect, and is with a mouse gavage LD50 3.07g/kg, the interaction between NIS and DNA can enhance the intensities of resonance light scattering(RLS) significantly, and the RLS intensity is increased with the increase of DNA concentration. The bactericidal mechanism is mainly involved in the combination of NIS with DNA to cause DNA mutations and finally result in bacterial death. Keyword ：Imidazoline;imidazolinyl-quaternary-ammonium-salt;naphthenicacid;bactericide;bactericidal mechanism 咪唑啉及其季铵盐可良好地用作炼油装置、油田采出水或酸清洗等场合的缓蚀剂，其缓 [1～5] [6] 蚀机理已研究得较为清楚 。环烷酸咪唑啉可作合成纤维POY 高速纺丝油剂杀菌剂 ，其