四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响_临床医学论文.docVIP

四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响_临床医学论文 四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响_临床医学论文 【摘要】 探讨四生汤对甲状腺激素致阴虚证小鼠的治疗作用及机制。 方法：选取健康昆明小鼠60只，随机分成6组。正常组和阴虚模型组予蒸馏水灌胃，低、中、高剂量四生汤组为治疗组，生脉饮为阳性对照药物，观察各组小鼠的一般生活状况并检测其自由活动能力和血清丙二醛的含量。 结果：四生汤能明显改善阴虚模型小鼠的口干、烦躁和体温升高（P＜0.05），提高小鼠的自由活动能力（P＜0.05），降低血清丙二醛的含量（P＜0.05）；但与生脉饮比较，差异无统计学意义（P＞0.05）。 结论：高、中剂量四生汤具有良好的养阴清热、生津止渴作用，可提高机体的活动能力和抗氧化损伤。 【关键词】 四生汤 阴虚 身体活动 抗氧化剂 小鼠 Zhang SF, Chen Z, Li B, Chen HY, Ling CQ, Wen XY. J Chin Integr Med/Zhong Xi Yi Jie He Xue Bao. 2008; 6(10): 1029 Received March 4, 2008; published online October 15, 2008. Free full text (PDF) is available at . Indexed/abstracted in and full text linkout at PubMed. Forward linking and reference linking via CrossRef. DOI: 10.3736/jcipen Access Effects of Sisheng Decoction on spontaneous activity and serum concentration of malondialdehyde in mice with yin deficiency sydrome Sufang ZHANG1, 2, Zhe CHEN1, Bai LI1, Hongyun CHEN1, Changquan LING1, Xinyu WEN3 1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China 2. Department of Integrated Traditional Chinese and Western Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China 3. Department of Biochemistry, Chinese Peoples Liberation Army General Hospital, Beijing 100088, China Objective: To assess the therapeutic effects of Sisheng Decoction, a compound traditional Chinese herbal medicine, on a mouse model of yin deficiency syndrome induced by thyroid hormone, and to make the preliminary study on its mechanisms. Methods: Simultaneous modeling and treatment were carried out. Sixty mice were randomly divided into six groups: normal group, yin deficiency model group, low, medium and highdose Sisheng Decoction group and Shengmai oral liquid group. Normal group and yin deficiency model group were administered with double distilled water. Spontaneous activity and serum concentration of malondialdehyde in different groups were detected. Results: