天麻钩藤饮对肝阳上亢型高血压患者抗氧化及颈动脉硬化的影响_临床医学论文.docVIP

天麻钩藤饮对肝阳上亢型高血压患者抗氧化及颈动脉硬化的影响_临床医学论文 天麻钩藤饮对肝阳上亢型高血压患者抗氧化及颈动脉硬化的影响_临床医学论文 作者：林展增　邢之华 刘卫平 刘青娥 【摘要】 目的：探讨天麻钩藤饮对肝阳上亢型高血压患者抗氧化活性以及颈动脉硬化的影响。方法：选择肝阳上亢型高血压患者60例，随机分为天麻钩藤饮组(中药组)和非洛地平组(对照组)各30例，治疗6个月，分别检测治疗前后患者血压、血清SOD、MDA以及颈动脉内中膜厚度(IMT)的变化。结果：治疗后，2组血压均明显下降，组间比较差异无显著性(Pgt;0.05)，天麻钩藤饮组和非洛地平组的SOD活性在治疗前分别为(85.6±11.2)U/mL和(86.3±12，5)U/mL，在治疗后为(98.1±12.8)U/mL和(95.1±13.2)U/mL，治疗后比较差异有显著性(0.01);MDA在治疗前为(6.28±1.65)nmol/L和(6.23±1.58)nmol/L，治疗后为(4.08±1.30)nmol/L和(5.11±1.39)nmol/L，治疗后比较差异有显著性(0.01)。天麻钩藤饮组IMT治疗前后分别为(1.16±0.14)mm和(0.75±0.08)mm，比较差异有显著性(0.01)。结论：天麻钩藤饮对肝阳上亢型高血压病患者具有良好降压作用,并且能增加抗氧化活性，改善高血压患者颈动脉硬化。 【关键词】 天麻钩藤饮;高血压;抗氧化剂;颈动脉疾病 　　【ABSTRACT】 Objective：To observe the effect of Tianmagouteng decoction on antioxygen and carotid artery atherosclerosis in hypertensive patients with hyperactivity of liver.Methods：Sixty hypertensive patients with hyperactivity of liver were randomly divided into tianmagouteng decoction group receiving tianmagouteng decoction treatment and felodipine group subject to felodipine.Before and 6 month after treatment,serum catalase(CAT)malonaldehyde(MDA)activity and carotid artery intimamedia thickness(IMT)were measured. Results：After 6 months of treatment，the blood pressure was declined in two groups and there was no significant difference between two groups(Pgt;0.05).The serum CAT was significantly increased in tianmagouteng decoction group compared with that of felodipine group(0.01);The serum MDA was significantly decreased in tianmagouteng decoction group compared with that of felodipine group(0.01).and the IMT significantly decreased in tianmagouteng decoction group compared with that of felodipine group(0.05).Conclusion：Tianmagouteng decoction can reduce IMT in the hypertensive patients with hyperactivity of liver，and increase antioxygen activity. 　　【KEY WORDS】 Tianmagouteng Decoction,Hypertension,Antioxidants,Carotid Artery Diseases 　　国内外研究表明，内皮功能障碍以及氧化应激在动脉硬化形成发展过程中起重要作用，临床研究表明天麻钩藤饮能改善血管内皮功能[1,2],本研究旨在进一步探讨天麻钩藤饮对肝阳上亢型高血压患者抗氧化活性以及颈动脉硬化的影响。 　　1 资料与方法