症状性颈内动脉狭窄患者抑郁与睡眠障碍的相关性研究①.pdfVIP

中国康复理论与实践2013年10月第19卷第10期ChinJRehabilTheoryPract,Oct.2013,Vol. 19,No. 10 - 953 - DOI: 10.3969/j.issn. 1006-9771.2013.10.014 ·临床研究 · 症状性颈内动脉狭窄患者抑郁与睡眠障碍的相关性研究① 王宁群，黄小波，陈文强，陈玉静 [摘要] 目的 探讨症状性(同侧血管缺血性卒中)颈内动脉重度狭窄患者抑郁与睡眠障碍的相关性。方法 根据汉密顿抑郁量 表(HAMD)评分，将符合研究标准的症状性颈内动脉狭窄患者分为抑郁组(n=92)和非抑郁组(n=82) 。将抑郁组分为轻度抑郁组(n= 36)和中度抑郁组(n=56) 。运用匹兹堡睡眠质量指数量表(PSQI)评价患者的睡眠状况。对PSQI 和HAMD 各维度评分进行相关性分 析。结果 抑郁组患者主观睡眠质量、睡眠潜伏期、睡眠持续性、习惯性睡眠效率、睡眠紊乱、使用睡眠药物、日间功能障碍及 PSQI 总分均明显高于非抑郁组(P0.01) 。中度抑郁组患者主观睡眠质量、睡眠潜伏期、睡眠紊乱、日间功能障碍及PSQI 总分均高 于轻度抑郁组(P0.05) 。PSQI 各维度中，睡眠紊乱、日间功能障碍与HAMD 各维度均明显相关(P0.01) ，睡眠潜伏维度及PSQI 总 分与除体重以外的其他HAMD 维度相关(P0.05) 。HAMD 各维度中，焦虑/躯体化、认识障碍、睡眠障碍与PSQI 各维度评分及 PSQI 总分相关(P0.05) 。结论 症状性颈内动脉狭窄患者抑郁与其睡眠质量密切相关，抑郁程度重者睡眠质量较差。 [关键词] 脑梗死；颈内动脉狭窄；抑郁；睡眠障碍 Relationship of Depression and Sleep Quality of Patients with Cerebral Ischemia and High-grade Atherosclerotic Internal Carotid Artery Stenosis WANG Ning- qun, HUANG Xiao- bo, CHEN Wen- qiang, et al. Xuanwu Hospital, Capital Medical University, Beijing 100053, China Abstract: Objective To explore the relationship of depression and sleep quality of patients with cerebral infarction and high-grade ath- erosclerotic internal carotid artery stenosis in acute seizure phase. Methods The patients targeted to the inclusion criteria were divided into non-depressive group (n=82) and depressive group (n=92) and the depressive group were divided into mild-depressive group (n=36) and moderate-depressive group (n=56) according to the Hamilton Rating Scale for Depressive (HAMD) score. Sleep quality was evaluated with Pittsburgh Sleep Quality Index (PSQI). The correlation was investigated between PSQI and HAMD score. Results The scores in the dimen- sions of subjective sleep quality, sleep latency,