alpha2A肾上腺素受体激动剂guanfacine增强大鼠Lashley迷宫空间学习能力,但不影响条件性恐惧记忆.pdfVIP

Acta Physiologica Sinica , December 25, 2007, 59 (6): 739-744 739 Research Paper The α2A -adrenoceptor agonist guanfacine improves spatial learning but not fear conditioning in rats 1 1 1,2,* JIN Xin-Chun , MA Chao-Lin , LI Bao-Ming 1Institute of Neurobiology, Institutes of Brain Science; 2State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China Abstract: It is known that stimulation of the α2A -adrenoceptors (α2A -ARs) by the selective α2A -AR agonist guanfacine produces an important and beneficial influence on prefrontal cortical (PFC) cognitive functions such as spatial working memory and selective attention. However, it is unclear whether stimulation of the α2A-ARs has a similar effect on fear conditioning that involves the amygdala and hippocampus. Here, we show that systemically administered guanfacine significantly enhances spatial learning of rats in the Lashley maze: compared with controls, the rats treated with guanfacine required significantly fewer trials and made significantly fewer errors to reach learning criterion. However, guanfacine produced no effect on acquisition of contextual and auditory fear memories. The present study suggests that beneficial effect of α2A -AR stimulation is task-dependent: guanfacine improves spatial learning but not fear conditioning. Key words: guanfacine; α2A-adrenoceptors; spatial learning; fear conditioning; rats α2A 肾上腺素受体激动剂guanfacine 增强大鼠空间学习能力而不影响条件性 恐惧记忆 1 1 1,2,* 金新春 ，马朝林 ，李葆明 1 2 复旦大学 脑科学研究院神经生物学研究所； 医学神经生物学国家重点实验室，上海 200032 摘 要：α2A 肾上腺素受体选择性激动剂guanfacine 对空间工作记忆和选择性注意等前额叶皮层认知功能有重要的、有益的影 响。然而，激活α2A 受体对于依赖杏仁体和海马回路的恐惧记忆条件反射是否有影响，目前尚不清楚。本研究结果显示， 全身给予guanfacine 显著提高大鼠在Lashley 迷宫中的空间学习能力：guanfacine 组大鼠达到学会标准所需要的训练次数和所犯错 误的次数显著少于生理盐水对照组大鼠。然而，guanfacine 组大鼠