适合MRI研究的羊颈髓压迫损伤模型的制作.pdfVIP

· 1526 · 中国医学影像技术 2008年第 24卷第 1o期 ChinJMedImagingTechnol，2008，Vol24，No10 · 实验研究 Establishmentofagoatcervicalspinalcordcompression injurymodelsuitableforMRIresearch LIUJi—CUlq ，LJUHuai—jun。，XUYing—jin ，ZHANGWei。，HEDan ，WANGZhi—hong (1．DepartmentofRadiology，3．DepartmentofSpinalSurgery，HebeiMedicalUniversity， theThirdHospital，Shijiazhuang050051，China；2．DepartmentofMedicalImaging， HebeiMedicalUniversity，theSecondHospital，S^Ji口 “口，2g050000，China) [Abstract] Objective ToestablishanewcervicalspinalcordcompressioninjurymodelsuitableforMRIresearchwith goat．Methods Ten goatsweighting 20— 25kg wererandomlydivided intotwogroups：compressiongroup and control group．A ballooncatheterwasinsertedintotheepiduralspaceviatheleftintervertabralforamanbetweenC2andC3foreach goat．TheballoonwaspositionedatthelevelofintervertabralspacebetweenC2andC3．Incompressiongroup，theballoon wasinflatedbyslow injectionof0．2mlofsaline10daysafteroperationandremainedfor40days．Incontrolgroup，thebal— loonwasnotinflated．GoatswereevaluatedwithMRI．1ocomotorratingscoreandpathology．Results Theballoonwaslo— catedinthelateral—ventralsideofthespinalcord．Beforetheballoonwasinflated，thesubaraehnoidspaceatthelevelofC23 becamenarrow andthespinalcordwasnotcompressed．Incompressiongroup，theballoonbecameovalandthespinalcord wasmoderatelycompressedaftertheballoonwasinflated．AlloftheMR imageswereclearwithoutapparentdistortion．In compressedgroup，thelocomotorratingscoresdecreased．Histopathologica1ly，swellinganddegenerationofaxonsandneu ronscouldbeseen．Conclusion Itisfeasibletoestablishagoatcervicalspinalcordcompressioninjurymodelwithballoon catheterviainterspinalforaman．Thedegree，speedanddurationofcompressionareundercontro1．Thecolumnkeepsintact andsatisfactor