超临界CO2制备硝苯地平纳微颗粒和其溶解性能.pdfVIP

第九届全国超临界流体技术学术及应用研讨会论文集 超临界COB 2B 制备硝苯地平纳微颗粒及其溶解性能TPF FPT 蔡建国 杨锋 华东理工大学 化学工程研究所， 上海, 200237 COB B 辅助膨胀通过同轴喷嘴雾化分散硝苯地平二氯甲烷溶液制备硝苯地平纳微颗粒地 论文研究了以超临界 2 -二氯甲烷溶液浓度、COB B温度和压力等参数，可控制硝苯地平纳微化 方法。研究结果显示，通过控制硝苯地平 2 颗粒尺寸大小和粒度分布，获得平均颗粒尺寸在 600~700nm的硝苯地平颗粒。溶出研究结果显示，相对于原料， 纳微化的硝苯地平能较快地达到溶解平衡，溶解平衡时间由原先的 60min下降到不足 40min 。 关键词：超临界COB2B ；膨胀雾化；硝苯地平；纳微颗粒 Micronization of nifedipine and its dissolving behavior Cai Jian-guo, Yang Feng East China University of Science and Technology, Chemical Engineering Research Institute, Product Engineering Dpartment，Shanghai, 200237 The nano/micro nifedipine particle formation was studied when the nifedipine-dichloromethane solution and the supercritical CO2B B mixted tohather through the special coaxial nozzle. The effect of concentration of nifedipine-dichloromethane, temperature and pressure of CO2B B on formed particle size and size distribution were experimental studied, and the results of SEM and particle size statistics show that the formed particle of nifedipine was average 600~700nm with narrow size distribution. The dissolving results show that the micronized nifedipine particle can quck to reach saturation and its dissolving time to reduce from 60min to less than 40min comparing with the original one. Key words：Supercritical COB2B ; atomization；nifedipine; nano/micro particle 硝苯地平用于不同疾病的治疗给药方式有所不同，如口服、口腔黏膜给药、鼻腔给药、注射 给药、透皮给药和植入型给药等等，为临床治疗高血压、心绞痛、心律失常等心血管疾病的常用